Reviews: Davis, Trends In Immunology, 2011 (doi:10.1016/j.it.2010.11.003): Lck is constitutively active, and it is recruited to TCR complex upon stimulation. apers: Herndon, Journal of Immunology, 2001 (doi:10.4049/jimmunol.166.9.5654): LAT-SLP-76 regulate NFkB activation in response to TCR/CD28. - In Jurkat cell line.

HGNC:1653 Reviews: Schulze-Luehrmann, Immunity, 2006 (doi:10.1016/j.immuni.2006.10.010): TCR signaling to NFkB. Miller, Immunological Research, 2009 (doi:10.1007/s12026-009-8097-6): Review on CD28. It mediates PKCtheta recruitment to the immunological synapse. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Isakov, Frontiers In Immunology, 2012 (doi:10.3389/fimmu.2012.00273): Signals from CD28 to PKC theta. Chen, Nature Reviews. Immunology, 2013 (doi:10.1038/nri3405): Co-signaling receptors. Papers: Salojin, Journal of Immunology, 1999 (PMID: 10395678): TCR and CD28 are coupled through Zap70 to the activation of Vav-Rac1-p38 pathway. - In Lck-negative JCaM1.6 cells, the human Jurkat cell line E6.1, P116 ZAP-70-deficient cell line (a variant of the Jurkat E6.1 T cell line), the EL4 mouse T cell line and CHO cells. Michel, The journal of Immunology, 2000 (doi:10.4049/jimmunol.165.7.3820): CD28 co-estimulatory signals require VAV1. - In Jurkat T cells and derivatives. Michel, Immunity, 2001: CD28 amplifies TCR signals at the level of PLCg and SLP76 through ITK activation. - In a Jurkat cell line (CH7C17) reconstituted with human CD28 wild-type (CD28WT) and Human CD4 T cells. Bauer, The Journal of Biological Chemistry, 2001 (doi:10.1074/jbc.M103098200): Akt and PKCtheta activation of NFkB. - In transfected Jurkat T cells. Herndon, Journal of Immunology, 2001 (doi:10.4049/jimmunol.166.9.5654): LAT-SLP-76 regulate NFkB activation in response to TCR/CD28. - In Jurkat cell line. Yu, The Journal of Immunology, 2001 (doi:10.4049/jimmunol.166.1.284): CREB activation by TCR/CD28 signals. - In EL4 T lymphoma cells. Holdorf, Nature Immunology, 2002 (doi:10.1038/ni761): CD4 and CD28 recruit an stabilize Lck at the immunological synapse. - In Jurkat T cells, DO11.10 T cells and 3.L2 T cells. Appleman, Journal of Immunology, 2002, (doi:10.4049/jimmunol.168.6.2729): CD28 and TCR signals mediate PI3K activation and Cell Cycle progression. Inferred. - In human peripheral T cells. Kim, The Journal of Immunology, 2006: CD28 co-stimulatory signals induce phosphorylation of PLCg, GRAP2, Vav1, ERK1/2 and p38. Sauer, PNAS, 2008 (doi:10.1073/pnas.0800928105): TCR/CD28 activate PI3K/Akt/mTOR pathway to induce FoxP3 expression. - In murine transgenic CD4 T cells. - In jurkat T cells. Byrum, Journal of Immunology, 2013 (doi:10.4049/jimmunol.1300485): CD28 costimulation. - In D10 T cells, Jurkat cells, JCaM1.6 T cells, and primary human T cells.

HGNC:1678 Papers: Holdorf, Nature Immunology, 2002 (10.1038/ni761): CD4 and CD28 recruit an stabilize Lck at the immunological synapse. - In Jurkat T cells, DO11.10 T cells and 3.L2 T cells. Li, Nature Immunology, 2004 (10.1038/ni1095): CD4 accumulates Lck at the Immunological Synapse. - In transfected (Lck-GFP) 5C.C7 T cell blasts.

HGNC:9666 Schoenborn, Scien Signaling, 2011 (10.1126/scisignal.2001893): LCK regulation by CD45 and CSK. In Jurkat T cell line E6-1, JCaM1, J45, P116 and J14 T cell lines.

HGNC:1691 Papers: Hassan, European Journal of Immunology, 2004 (doi:10.1002/eji.200424856): CD6 in T cell activation. Hassan, Journal of Cellular Biology, 2006 (doi:10.1128/MCB.00688-06): CD6 costimulation requires SLP-76. - In Jurkat and Human primary T cells. Roncagalli, Nature Immunology, 2014 (doi:10.1038/ni.2843): Proteomics of ZAP70. - In murine primary CD4 T cells. Breuning, Molecular and Cellular Biology, 2017, (doi: 10.1128/MCB.00071-17): CD6-GADS-SLP76. - In human primary CD4 T cells and Jurkat T cell line.

Reviews: Kane, Current Opinion in Immunology (doi:10.1016/S0952-7915(00)00083-2): TCR signaling review. Huang, Journal Of Biological Chemistry, 2004 (doi:10.1074/jbc.R400012200): Review on TCR signaling. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Papers: Salojin, Journal of Immunology, 1999 (PMID: 10395678): TCR and CD28 are coupled through Zap70 to the activation of Vav-Rac1-p38 pathway. - In Lck-negative JCaM1.6 cells, the human Jurkat cell line E6.1, P116 ZAP-70-deficient cell line (a variant of the Jurkat E6.1 T cell line), the EL4 mouse T cell line and CHO cells.

Reviews: Schulze-Luehrmann, Immunity, 2006 (doi:10.1016/j.immuni.2006.10.010): TCR signaling to NFkB. Miller, Immunological Research, 2009 (doi:10.1007/s12026-009-8097-6): Review on CD28. It mediates PKCtheta recruitment to the immunological synapse. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Isakov, Frontiers In Immunology, 2012 (doi:10.3389/fimmu.2012.00273): Signals from CD28 to PKC theta. Chen, Nature Reviews. Immunology, 2013 (doi:10.1038/nri3405): Co-signaling receptors. Papers: Kim, Journal of Biological Chemistry, 1998 (doi:10.1074/jbc.273.1.296): Grb2 interaction with CD28 and its role in costimulation. - In the murine T cell hybridoma DC27.10, CHO cells, and CHO-CD86 cells. Michel, The journal of Immunology, 2000 (doi:10.4049/jimmunol.165.7.3820): CD28 co-estimulatory signals require VAV1. - In Jurkat T cells and derivatives. Michel, Immunity, 2001: CD28 amplifies TCR signals at the level of PLCg and SLP76 through ITK activation. - In a Jurkat cell line (CH7C17) reconstituted with human CD28 wild-type (CD28WT) and Human CD4 T cells. Herndon, Journal of Immunology, 2001 (doi:10.4049/jimmunol.166.9.5654): LAT-SLP-76 regulate NFkB activation in response to TCR/CD28. - In Jurkat cell line. Kim, The Journal of Immunology, 2006: CD28 co-stimulatory signals induce phosphorylation of PLCg, GRAP2, Vav1, ERK1/2 and p38. - In jurkat T cells. Higo, Immunological Investigations, 2014 (doi:10.3109/08820139.2013.875039): CD28-GADS interaction. - Isolated proteins.

HGNC:1691 Papers: Hassan, European Journal of Immunology, 2004 (doi:10.1002/eji.200424856): CD6 in T cell activation. Hassan, Journal of Cellular Biology, 2006 (doi:10.1128/MCB.00688-06): CD6 costimulation requires SLP-76. - In Jurkat and Human primary T cells. Roncagalli, Nature Immunology, 2014 (doi:10.1038/ni.2843): Proteomics of ZAP70. - In murine primary CD4 T cells. Breuning, Molecular and Cellular Biology, 2017, (doi: 10.1128/MCB.00071-17): CD6-GADS-SLP76. - In human primary CD4 T cells and Jurkat T cell line.

HGNC:6524 Reviews: Huang, Journal Of Biological Chemistry, 2004 (10.1074/jbc.R400012200): T Cell eceptor complexes. Salmond, Immunological Reviews, 2009 (10.1111/j.1600-065X.2008.00745.x): LCK and FYN function in TCR signaling to activate T Cells. Davis, Trends In Immunology, 2011 (doi:10.1016/j.it.2010.11.003): Lck is constitutively active, and it is recruited to TCR complex upon stimulation. Palacios, Oncogene, 2004 (doi:10.1038/sj.onc.1208074): Fyn and Lck regulation and functions. Papers: Schoenborn, ScienSignaling, 2011 (10.1126/scisignal.2001893): LCK regulation by CD45 and CSK. - In Jurkat T cell line E6-1, JCaM1, J45, P116 and J14 T cell lines. Ballek, Immunology Letters, 2012 (10.1016/j.imlet.2012.01.001): Active Lck (pTyr394) is recruited to TCR ITAMs upon TCR activation. - In mouse primary T cells. Rossy, Nature Immunology, 2013 (10.1038/ni.2488):Regulation of LCK in early TCR signaling. - In Jurkat T cell line JCaM1. Ballek, Immunology And Cell Bioloy, 2015 (10.1038/icb.2014.100): Pre-activated LCK and its regulation. - Mouse T cells, SYF and JCAM1.6 Jurkat T-cell lines.

HGNC:6524 Reviews: Kane, Current Opinion in Immunology, 2000 (doi:10.1016/S0952-7915(00)00083-2): TCR signaling review. Huang, Journal Of Biological Chemistry, 2004 (doi:10.1074/jbc.R400012200): T Cell eceptor complexes. Salmond, Immunological Reviews, 2009 (doi:10.1111/j.1600-065X.2008.00745.x): LCK and FYN function in TCR signaling to activate T Cells. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Wang, Cold Spring Harbor Perspectives in Biology, 2010 (10.1101/cshperspect.a002279): ZAP70 structure and functions. Davis, Trends In Immunology, 2011 (doi:10.1016/j.it.2010.11.003): Lck is constitutively active, and it is recruited to TCR complex upon stimulation. Kannan, The International Journal of Biochemistry and Cell Biology, 2012 (doi:10.1016/j.biocel.2012.08.023): TCR signaling review. Brownlie, Nature Reviews. Immunology, 2013 (doi:10.1038/nri3403): Review on TCR signaling network. Palacios, Oncogene, 2004 (doi:10.1038/sj.onc.1208074): Fyn and Lck regulation and functions. Chakraborty and Weiss, Nature Immunology, 2014 (doi:10.1038/ni.2940): PTPN22 dephosphorylates LCK pTyr394. Malissen, Annual Reviews. Immunology, 2015 (10.1146/annurev-immunol-032414-112158): Review on early T cell activation. Papers: Holdorf, Nature Immunology, 2002 (doi:10.1038/ni761): CD4 and CD28 recruit an stabilize Lck at the immunological synapse. - In Jurkat T cells, DO11.10 T cells and 3.L2 T cells. Stefanova, Nature Immunology, 2003 (doi:10.1038/ni895): ERK phosphorylates LCK and prevents PTPN6 (SHP1)-mediated LCK inhibition. - In mouse T cells, 5C.C7 T cells, and 293T cells. Schoenborn, ScienSignaling, 2011 (doi:10.1126/scisignal.2001893): LCK regulation by CD45 and CSK. - In Jurkat T cell line E6-1, JCaM1, J45, P116 and J14 T cell lines. Ballek, Immunology Letters, 2012 (doi:10.1016/j.imlet.2012.01.001): Active Lck (pTyr394) is recruited to TCR ITAMs upon TCR activation. - In mouse primary T cells. Rossy, Nature Immunology, 2013 (doi:10.1038/ni.2488):Regulation of LCK in early TCR signaling. - In Jurkat T cell line JCaM1. Poltorak, Cell Communication And Signaling, 2013 (doi:10.1186/1478-811X-11-4): TCR signaling dynamics. - In human primary T cells and Jurkat T-cell line J.CaM1.6. Ballek, Immunology And Cell Bioloy, 2015 (doi:0.1038/icb.2014.100): Pre-activated LCK and its regulation. - Mouse T cells, SYF and JCAM1.6 Jurkat T-cell lines. Klammt, Nature Immunology, 2015 (doi:10.1038/ni.3231): Lck activates and stabilizes ZAP70 by phosphorylation. - In Jurkat P116 cell line.

HGNC:4037 Reviews: Palacios, Oncogene, 2004 (doi:10.1038/sj.onc.1208074): Fyn and Lck regulation and functions. Solheim, The Journal of Biological Chemistry, 2008 (doi:10.1074/jbc.M705215200): PAG is phosphorylated by FYN which recruits CSK to the Immunological synapse. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Salmond, Immunological Reviews, 2009 (doi:10.1111/j.1600-065X.2008.00745.x): LCK and FYN function in TCR signaling to activate T Cells. Brownlie, Nature Reviews. Immunology, 2013 (doi:10.1038/nri3403): Review on TCR signaling. Papers: Lovatt, Molecular and Cellular Biology, 2006 (doi:10.1128/MCB.00168-06): Lck regulates threshold and Lck and Fyn regulate magnitud in TCR signaling. - In mouse CD4 T cells

HGNC=3796 Reviews: Macián, Oncogene, 2001 (doi:10.1038/sj.onc.1204386): NFAT and AP-1 activation. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Meng, Protein and Cell, 2011 (doi:10.1007/s13238-011-1113-3):Review of cJun. Papers: Appleman, Journal of Immunology, 2002, (doi:10.4049/jimmunol.168.6.2729): CD28 and TCR signals mediate PI3K activation and Cell Cycle progression. - In human primary T cells. Charvet, The Journal of Biological Chemistry, 2002 (doi:10.1074/jbc.M111627200): VAV1 and VAV2 mediate SRF activation and c-FOS expresion through RAC1/CDC42 pathways. - In Jurkat T cells (clone JE6.1), and simian virus 40 T antigen-transfected human leukemic Jurkat T cells (Jurkat-TAg).

HGNC=6204 Reviews: Macián, Oncogene, 2001 (doi:10.1038/sj.onc.1204386): NFAT and AP-1 activation. Dong, Annual Review of Immunology, 2002 (doi:10.1146/annurev.immunol.20.091301.131133): MAP kinases in immune response. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Meng, Protein and Cell, 2011 (doi:10.1007/s13238-011-1113-3):Review of cJun. Papers. Gotschel, Experimental Cell Research, 2008 (doi:10.1016/j.yexcr.2007.12.015):GSK3b regulates inhibitoon b-Catenin, AP-1 and CREB. - In mouse hepatocytes.

HGNC:6877 HGNC:6871 Reviews: Kane, Current Opinion in Immunology, 2000 (doi:10.1016/S0952-7915(00)00083-2): TCR signaling review. Rincón, Oncogene, 2001 (doi: 10.1038/sj.onc.1204382): MAP kinases in T cell activation. Dong, Annual Review of Immunology, 2002 (doi:10.1146/annurev.immunol.20.091301.131133): MAP kinases in immune response. Isakov, Annual Reviews. Immunology, 2002 (doi:10.1146/annurev.immunol.20.120701.074321): PKC theta in TCR/CD28 signaling. Tybulewicz, Current Opinion in Immunology, 2005 (doi:10.1016/j.coi.2005.04.003): Review on VAV proteins. Indirect role in ERK activation. Symons, TRENDs in Immunology, 2006 (10.1016/j.it.2005.11.007): MAPKs in Immunity. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Meng, Protein and Cell, 2011 (doi:10.1007/s13238-011-1113-3):Review of cJun. Papers: Salojin, Journal of Immunology, 1999 (PMID: 10395678): TCR and CD28 are coupled through Zap70 to the activation of Vav-Rac1-p38 pathway. - In Lck-negative JCaM1.6 cells, the human Jurkat cell line E6.1, P116 ZAP-70-deficient cell line (a variant of the Jurkat E6.1 T cell line), the EL4 mouse T cell line and CHO cells. Yu, The Journal of Immunology, 2001 (doi:10.4049/jimmunol.166.1.284): CREB activation by TCR/CD28 signals. - In EL4 T lymphoma cells. Appleman, Journal of Immunology, 2002, (doi:10.4049/jimmunol.168.6.2729): CD28 and TCR signals mediate PI3K activation and Cell Cycle progression. - In human primary T cells. Charvet, The Journal of Biological Chemistry, 2002 (doi:10.1074/jbc.M111627200): VAV1 and VAV2 mediate SRF activation and c-FOS expresion through RAC1/CDC42 pathways. - In Jurkat T cells (clone JE6.1), and simian virus 40 T antigen-transfected human leukemic Jurkat T cells (Jurkat-TAg). Stefanová, Nature Immunology, 2003 (doi:10.1038/ni895): ERK blocks SHP-1 inhibition of LCK. - In mouse T cells, 5C.C7 T cells, and 293T cells. Reynolds, The Journal of Biological chemistry, 2004 (doi:10.1074/jbc.M400257200): Vav1 functions in TCR signaling. - In mouse thymocites Poltorak, Cell Communication And Signaling, 2013 (doi:10.1186/1478-811X-11-4): TCR signaling dynamics. - In human primary T cells and Jurkat T-cell line J.CaM1.6. Byrum, Journal of Immunology, 2013 (10.4049/jimmunol.1300485): CD28 costimulation. - In D10 T cells, Jurkat cells, JCaM1.6 T cells, and primary human T cells. Helou, Plos ONE, 2013 (doi:10.1371/journal.pone.0069641): Erk positive role in TCR signaling. - In Jurkat T cells (E6-1 clone) were

HGNC:20184 HGNC:6886 Reviews: Rincón, Oncogene, 2001 (doi: 10.1038/sj.onc.1204382): MAP kinases in T cell activation. Dong, Annual Review of Immunology, 2002 (doi:10.1146/annurev.immunol.20.091301.131133): MAP kinases in immune response. Cuenda, The International Journal of Biochemistry and Cell Biology, 2002 (PMID:10785355): MKK4 activates JNK. Symons, TRENDs in Immunology, 2006 (doi:10.1016/j.it.2005.11.007): MLK3 promotes JNK activation in Jurka T cells. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Indirect. Meng, Protein and Cell, 2011 (doi:10.1007/s13238-011-1113-3):Review of cJun. Chuang, Advances in Immunology, 2015 (doi:10.1016/bs.ai.2015.09.006): MAP4Ks in Immunity. Papers: Kumabe, Microbiology and Immunology, 2010 (doi:10.1111/j.1348-0421.2009.00188.x): DUSP16 negatively regulates JNK. - In murine naive CD4 and CD8 T cells.

HGNC:6876 Reviews: Kane, Current Opinion in Immunology, 2000 (doi:10.1016/S0952-7915(00)00083-2): TCR signaling review. Dong, Annual Review of Immunology, 2002 (doi:10.1146/annurev.immunol.20.091301.131133): MAP kinases in immune response. Rudd, Nature Immunoogy, 2005 (doi:10.1038/ni0405-368): Pathways of P38a activation in T cells. Symons, TRENDs in Immunology, 2006 (10.1016/j.it.2005.11.007): MLK3 promotes JNK activation in Jurka T cells. Papers: Salojin, Journal of Immunology, 1999 (PMID: 10395678): TCR and CD28 are coupled through Zap70 to the activation of Vav-Rac1-p38 pathway. - In Lck-negative JCaM1.6 cells, the human Jurkat cell line E6.1, P116 ZAP-70-deficient cell line (a variant of the Jurkat E6.1 T cell line), the EL4 mouse T cell line and CHO cells. Yu, The Journal of Immunology, 2001 (doi:10.4049/jimmunol.166.1.284): CREB activation by TCR/CD28 signals. - In EL4 T lymphoma cells. Salvador, Nature Immunology, 2005 (doi:10.1038/ni1177): P38 pathway mediated by ZAP70. - In murine CD4 T cells and Jurkat T cells. Salvador, Nature Immunology, 2005 (doi:10.1038/ni1176): P38 pathway mediated by ZAP70. - In murine CD4 and CD8 T cells.

HGNC:9955 (RELA) HGNC:7794 (NFkB1) Reviews: Coudronniere, PNAS, 2000 (10.1073/pnas.060028097): TCR/CD28 activate NFkB through PKC theta Isakov, Annual Reviews. Immunology, 2002 (doi:10.1146/annurev.immunol.20.120701.074321): PKC theta in TCR/CD28 signaling. Schulze-Luehrmann, Immunity, 2006 (doi:10.1016/j.immuni.2006.10.010): TCR signaling to NFkB. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Papers: Bauer, The Journal of Biological Chemistry, 2001 (doi:10.1074/jbc.M103098200): Akt and PKCtheta activation of NFkB. - In transfected Jurkat T cells. Herndon, Journal of Immunology, 2001 (doi:10.4049/jimmunol.166.9.5654): LAT-SLP-76 regulate NFkB activation in response to TCR/CD28. - In Jurkat cell line. Cheng, The Journal of Biological Chemistry (doi:10.1074/jbc.M111.259549): Role of Akt in NFkB-dependent transcriptional regulation. - In D10 Tcell clone and cD4 T cells from DO11.10 TCR transgenic mice.

HGNC=6204 HGNC=3796 Reviews: Macián, Oncogene, 2001 (doi:10.1038/sj.onc.1204386): NFAT and AP-1 activation. Saibil, Current Opinion in Immunology, 2007 (10.1016/j.coi.2007.08.005): Anergy and Cell Cycle. Zheng, EMBO Reports, 2008 (doi:10.1038/sj.embor.7401138): Anergy in T cells. Meng, Protein and Cell, 2011 (doi:10.1007/s13238-011-1113-3):Review of cJun. Papers: Yeh, Molecular and Cellular Biology, 2001 (doi:10.1128/MCB.21.14.4515-4527.2001): CREB and AP-1 promote IL-2 expression. - In Jurkat T-cell clone JH6.2 and the CD28-deficient Jurkat cell clone JF3 , and in human primary T Cells. Appleman, Journal of Immunology, 2002, (doi:10.4049/jimmunol.168.6.2729): CD28 and TCR signals mediate PI3K activation and Cell Cycle progression. - In human primary T cells.

HGNC:7776 (NFAT1) HGNC:7775 (NFAT2) Reviews: Macián, Oncogene, 2001 (doi:10.1038/sj.onc.1204386): NFAT and AP-1 activation. Hogan, Genes and Development, 2003 (doi:10.1101/gad.1102703.GENES): Calcineurin/NFAT pathway. Saibil, Current Opinion in Immunology, 2007 (10.1016/j.coi.2007.08.005): Anergy and Cell Cycle. Zheng, EMBO Reports, 2008 (doi:10.1038/sj.embor.7401138): Anergy in T cells. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Gachet, General physiology and biophysics, 2009 (PMID: 20093726): Calcineuron/NFAT signaling. Liu, Immunological Reviews, 2009 (doi:10.1111/j.1600-065X.2008.00756.x): Cabin1 Hermann-Kleiter, BLOOD, 2010 (doi:10.1182/blood-2009-10-233585.): NFAT medaited cytokine expression. Papers: Rincón, Molecular and Cellular Biology, 1997 (PMID:032280): NFAT induce Th2 differentiation. - In T cells from lymph nodes of NFAT-Luc transgenic mice. Foucault, BLOOD,2005 (doi:10.1182/blood-2003-08-2965):3BP2 intracts with Vav and regulates NFAT activation. Through PLCg1 perhaps. - In the human B (BJAB, RPMI8866, Daudi, and Raji) and T (Jurkat) cell lines.

HGNC:2345 Reviews: Mayr, Nature Reviews. Molecular Cell Biology, 2001 (doi:10.1038/35085068): Review on CREB. Hemmings, Cold Spring Harbor Perspectives in Biology, 2012 (doi:10.1101/cshperspect.a011189): PI3K pathway. Papers: Yeh, Molecular and Cellular Biology, 2001 (doi:10.1128/MCB.21.14.4515-4527.2001): CREB and AP-1 promote IL-2 expression. - In Jurkat T-cell clone JH6.2 and the CD28-deficient Jurkat cell clone JF3 , and in human primary T Cells. Yu, The Journal of Immunology, 2001 (doi:10.4049/jimmunol.166.1.284): CREB activation by TCR/CD28 signals. - In EL4 T lymphoma cells. Appleman, Journal of Immunology, 2002, (doi:10.4049/jimmunol.168.6.2729): CD28 and TCR signals mediate PI3K activation and Cell Cycle progression. Inferred. - In human peripheral T cells. Gotschel, Experimental Cell Research, 2008 (doi:10.1016/j.yexcr.2007.12.015):GSK3b regulates inhibitoon b-Catenin, AP-1 and CREB. - In mouse hepatocytes.

HGNC:2514 Reviews: Yu, Immunological Research, 2010 (doi:10.1007/s12026-009-8137-2): b-Catenin in t cell function. Papers: Gotschel, Experimental Cell Research, 2008 (doi:10.1016/j.yexcr.2007.12.015):GSK3b regulates inhibitoon b-Catenin, AP-1 and CREB. - In mouse hepatocytes.

HGNC:11291 Papers: Tartare-Deckert, Journal of Biological Chemistry, 2001 (doi:10.1074/jbc.M010588200): Vav2 and Vav1 activate c-Fos Serum Response Element. - In Simian virus 40 T antigen-transfected human leukemic Jurkat T cells (Jurkat-TAg) and Jurkat clone JE6.1. Charvet, The Journal of Biological Chemistry, 2002 (doi:10.1074/jbc.M111627200): VAV1 and VAV2 mediate SRF activation and c-FOS expresion through RAC1/CDC42 pathways. - In Jurkat T cells (clone JE6.1), and simian virus 40 T antigen-transfected human leukemic Jurkat T cells (Jurkat-TAg).

Reviews: Tybulewicz, Current Opinion in Immunology, 2005 (doi:10.1016/j.coi.2005.04.003): Review on VAV proteins. Gu, Immunological Reviews, 2009 (doi:10.1111/j.1600-065X.2008.00751.x): Review on Abl. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Matalon, Immunological Reviews, 2013 (doi:10.1111/imr.12112): Actin remodeling Papers: Kaga, Journal of Immunology, 1998: Rac1 in the rearrangement of Cytoskeleton. - In mouse T cell line EL4. Kim, Nature, 2000 (doi:10.1038/35004513): Regulations of WASp activation. - Purified recombinant proteins. Labno, Current Biology, 2003 (doi:10.1016/j.cub.2003.08.005): Itk role in Actin remodeling. - In primary T cell blasts from wild-type (wt), Itk-/-, Rlk-/-,or Rlk-/- Itk-/- TCR transgenic mice. Gomez, Immunity, 2006, (doi:10.1016/j.immuni.2006.03.022): HS1 regulates actin remodeling. - In Jurkat T cells, pri-mary human CD4+ T cells, and murine DO11.10 TCR Tg T cells. Huang, BLOOD, 2008 (doi:10.1182/blood-2007-10-118232): Abl role in actin remodeling. - In Jurkat T cells and mouse primary CD4 T cells. Chemin, Journal of Immunology, 2012 (doi:10.4049/jimmunol.1200156): CDC42 regulates actin remodeling. - In Human primary CD4+ T cells and Jurkat J77 cl20 T cells.

Reviews. Kovalovsky, Journal of Neuroimmunology, 2000 (doi:10.1016/S0165-5728(00)00298-8): Th1 and th2 Cytokines. Macián, Oncogene, 2001 (doi:10.1038/sj.onc.1204386): NFAT and AP-1 activation. Hermann-Kleiter, BLOOD, 2010 (doi:10.1182/blood-2009-10-233585.): NFAT medaited cytokine expression.

Reviews: Kovalovsky, Journal of Neuroimmunology, 2000 (doi:10.1016/S0165-5728(00)00298-8): Th1 and th2 Cytokines. Macián, Oncogene, 2001 (doi:10.1038/sj.onc.1204386): NFAT and AP-1 activation. Baine, Immunological Reviews, 2009 (doi:10.1111/j.1600-065X.2009.00817.x): NFAT induces anti-inflammatory cytokins. Hermann-Kleiter, BLOOD, 2010 (doi:10.1182/blood-2009-10-233585.): NFAT medaited cytokine expression. Papers: Rincón, Molecular and Cellular Biology, 1997 (PMID:032280): NFAT induce Th2 differentiation. - In T cells from lymph nodes of NFAT-Luc transgenic mice.

Reviews: Bauer, Molecular Immunology, 2002 (10.1016/S0161-5890(02)00011-1): PKC and Akt are partners in TCR/CD28 signaling. Okkenhaug, Biochemical Society Transactions, 2004: PI3K role in T cell activation. Saibil, Current Opinion in Immunology, 2007 (10.1016/j.coi.2007.08.005): Anergy and Cell Cycle. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Meng, Protein and Cell, 2011 (doi:10.1007/s13238-011-1113-3):Review of cJun. Newton, Frontiers in Immunology, 2012 (10.3389/fimmu.2012.00151): PTEN in T cells. Chen, Nature Reviews. Immunology, 2013 (10.1038/nri3405): Co-signaling receptors. Papers: Yeh, Molecular and Cellular Biology, 2001 (doi:10.1128/MCB.21.14.4515-4527.2001): CREB and AP-1 promote IL-2 expression. - In Jurkat T-cell clone JH6.2 and the CD28-deficient Jurkat cell clone JF3 , and in human primary T Cells. Appleman, Journal of Immunology, 2002, (doi:10.4049/jimmunol.168.6.2729): CD28 and TCR signals mediate PI3K activation and Cell Cycle progression. - In human primary T cells. Ouyang, Nature, 2012 (10.1038/nature11581): Foxo1-dependent transcriptional programs. - Mouse mutant T reg cells.

Reviews: Bauer, Molecular Immunology, 2002 (doi:10.1016/S0161-5890(02)00011-1): PKC and Akt are partners in TCR/CD28 signaling. Okkenhaug, Biochemical Society Transactions, 2004 (doi:10.1042/): PI3K role in T cell activation. Takada, Nature Reviews. Immunology, 2009 (doi:10.1038/nri2657): T cell homeostasis. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Meng, Protein and Cell, 2011 (doi:10.1007/s13238-011-1113-3):Review of cJun. Hemmings, Cold Spring Harbor Perspectives in Biology, 2012 (doi:10.1101/cshperspect.a011189): PI3K pathway. Newton, Frontiers in Immunology, 2012 (doi:10.3389/fimmu.2012.00151): PTEN in T cells. Chen, Nature Reviews. Immunology, 2013 (doi:10.1038/nri3405): Co-signaling receptors. Hermida, Advances in Biological Regulation, 2017 (doi:10.1016/j.jbior.2017.06.003): GSK3b functions.

Reviews: Macián, Oncogene, 2001 (doi:10.1038/sj.onc.1204386): NFAT and AP-1 activation. Saibil, Current Opinion in Immunology, 2007 (10.1016/j.coi.2007.08.005): Anergy and Cell Cycle. Zheng, EMBO Reports, 2008 (doi:10.1038/sj.embor.7401138): Anergy in T cells. Baine, Immunological Reviews, 2009 (doi:10.1111/j.1600-065X.2009.00817.x): NFAT induces anti-inflammatory cytokins.

HGNC:76 Reviews: Wang, Current Biology, 2004 (doi:10.1016/j.cub.2004.07.012): Review on Abl. Gu, Immunological Reviews, 2009 (doi:10.1111/j.1600-065X.2008.00751.x): Review on Abl. Papers: Zipfel, Current Biology, 2004 (doi:10.1016/j.cub.2004.07.021): Abl phosphorylates ZAP70. - In murine splenic T cells and Jurkat T cells. Huang, BLOOD, 2008 (doi:10.1182/blood-2007-10-118232): Abl role in actin remodeling. - In Jurkat T cells and mouse primary CD4 T cells.

HGNC:12858 Reviews: Kane, Current Opinion in Immunology, 2000 (doi:10.1016/S0952-7915(00)00083-2): TCR signaling review. August, The Journal Of Biochemistry And Celullar Biology, 2002 (doi:10.1016/S1357-2725(02)00068-7): Lck phosphorylates and activates ZAP70, Itk and Rlk. Zap70 phosphorylates LAT and SLP76. Itk and Rlk phosphorylate PLCg. Saito, Immunological Reviews, 2003 (PMID:12670402): Negatve feedback of T cell activation. Huang, Journal of Biological Chemistry, 2004 (doi:10.1074/jbc.R400012200): Review on TCR signaling. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Gu, Immunological Reviews, 2009 (doi:10.1111/j.1600-065X.2008.00751.x): Review on Abl. Au-Yeung, Immunological Reviews, 2009 (10.1111/j.1600-065X.2008.00753.x): Zap70 regulation and functions. Wang, Cold Spring Harbor Perspectives in Biology, 2010 (10.1101/cshperspect.a002279): ZAP70 structure and functions. Kannan, The International Journal of Biochemistry and Cell Biology, 2012 (doi:10.1016/j.biocel.2012.08.023): TCR signaling review. Brownlie, Nature Reviews. Immunology, 2013 (doi:10.1038/nri3403): Review on TCR signaling. Bartelt, Wiley interdisciplinary reviews. Systems biology and medicine, 2013 (doi:10.1002/wsbm.1194): LAT integrate signals from TCR. Chakraborty and Weiss, Nature Immunology, 2014 (doi:10.1038/ni.2940) Lck phosphorylates and activates ZAP70 when recruited to phosphorilated Z of TCR complex. Malissen, Annual Reviews. Immunology, 2014 (doi:10.1146/annurev-immunol-032414-112158): Review on early T cell activation. Papers: Williams, The EMBO Journal, 1999 (doi:10.1093/emboj/18.7.1832): Tyr319 phosphorylation is important for ZAP70 mediated Ras and PLCg activation. - In Jurkat clone E6 and Jurkat-derived P116 cells, and COS-1 cells. Salojin, Journal of Immunology, 1999 (PMID: 10395678): TCR and CD28 are coupled through Zap70 to the activation of Vav-Rac1-p38 pathway. - In Lck-negative JCaM1.6 cells, the human Jurkat cell line E6.1, P116 ZAP-70-deficient cell line (a variant of the Jurkat E6.1 T cell line), the EL4 mouse T cell line and CHO cells. Herndon, Journal of Immunology, 2001 (doi:10.4049/jimmunol.166.9.5654): LAT-SLP-76 regulate NFkB activation in response to TCR/CD28. - In Jurkat cell line. Yamasaki, Journal of Biological Chemistry, 2001 (doi:10.1074/jbc.M105384200): GAB2 recruitment and activation. - In T cell lines: 21-1-8, Jurkat and 2B4. Zipfel, Current Biology, 2004 (doi:10.1016/j.cub.2004.07.021): Abl phosphorylates ZAP70. - In murine splenic T cells and Jurkat T cells. Qu, Biochemistry, 2005 (doi:10.1021/bi048353o): Function of 3BP2 phosphorylation. - In Jurkat T lymphocytes expressing SV40 large T antigen (Jurkat-TAg cells). Poltorak, Cell Communication And Signaling, 2013 (doi:10.1186/1478-811X-11-4): TCR signaling dynamics. - In human primary T cells and Jurkat T-cell line J.CaM1.6.

HGNC:18874 Reviews: Leo, Current Opinion In Immunology, 2002 (doi:10.1172/JCI200214942): Grb2-Sos complex is recruited to phosphorylated LAT. Huang, Journal Of Biological Chemistry, 2004 (doi:10.1074/jbc.R400012200): Review on TCR signaling. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Readinger, Immunological Reviews, 2009 (doi:10.1111/j.1600-065X.2008.00757.x): Review on Tec kinases. Brownlie, Nature Reviews. Immunology, 2013 (doi:10.1038/nri3403): Review on TCR signaling. Bartelt, Wiley interdisciplinary reviews. Systems biology and medicine, 2013 (doi:10.1002/wsbm.1194): LAT integrate signals from TCR. Malissen, Nature Immunology, 2014 (doi:10.1038/ni.2959): LAT signalosome during TCR signaling. Bagalopalan, Journal of Biological Chemistry, 2015 (doi:10.1074/jbc.R115.665869): LAT signalosome. Papers: Liu, Current Biology, 1999 (10.1016/S0960-9822(99)80017-7):LAT-GADS-SLP76 - In Jurkat and Raji cells. Zhang, The Journal of Biological Chemistry, 2000 (doi:10.1074/jbc.M000404200): GRB2, GADS y PLC gamma 1 are recruited to phosphorylated LAT. - In Jurkat cells (E6.1) and LAT-deficient cells (J.CaM2.5). Yamasaki, Mollecular And Cellular Biology, 2003 (doi:10.1128/MCB.23.7.2515): GAB2 interacts with GRAP2 and GRB2 for inhibiting TCR signals. - Jurkat T, Jurkat J.EcoR cells, LAT-deficient Jurkat cell line J.CaM2.5, and SLP- 76-deficient Jurkat cell line J.14. Shim, Journal of Immunology, 2011 (doi:10.4049/jimmunol.1001785): LAT and SLP76 are necesary for PI3K activation. - In Jurkat T cells (wt, J14 and JCam2). Bagalopalan, Journal of Immunology, 2013 (doi:10.4049/jimmunol.1202760): LAT activation in microclusters. - Jurkat E6.1 and LAT-deficient JCam2.5. Kortum, Science Signaling, 2013 (doi:10.1126/scisignal.2004494): SOS1 ability to oligomerize with LAT. - In DP thymocites. Kortum, Science Signaling, 2013 (doi:10.1126/scisignal.2004494): SOS1 ability to oligomerize with LAT. - In DP thymocites. Bilal, Cellular Signaling, 2015 (doi:10.1016/j.cellsig.2015.01.012): GADS relevance for SLP76 and PLCg recruitment to LAT and Cytokine expression. - Human CD4 T cells.

HGNC:6529 Reviews: Schaefer, Current Opinion In Immunology, 2000 (doi:10.1016/S0952-7915(00)00088-1): ZAP70 mediates SLP76 phosphorylation. Leo, Current Opinion In Immunology, 2002 (doi:10.1172/JCI200214942): LCP2 (SLP76) is recruited to LAT through GADS(GRAP2), where it is phosphorylated. Huang, Journal Of Biological Chemistry, 2004 (doi:10.1074/jbc.R400012200): Review on TCR signaling. Qi, Science's STKE : signal transduction knowledge environment, 2007 (doi:10.1126/stke.3962007pe39): On SLP-76 - ITK interaction. Felices, Advances In Immunology, 2007 (doi:10.1016/S0065-2776(06)93004-1): Itk and Rlk phosphorylate PLCg with the requirement of LAT-SLP76. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Readinger, Immunological Reviews, 2009 (doi:10.1111/j.1600-065X.2008.00757.x): Review on Tec kinases. Brownlie, Nature Reviews Immunology, 2013 (doi:10.1038/nri3403): SLP76 is recruited to phosphorylated LAT by GADS. Bartelt, Wiley interdisciplinary reviews. Systems biology and medicine, 2013 (doi:10.1002/wsbm.1194): LAT integrate signals from TCR. Malissen, Nature Immunology, 2014 (doi:10.1038/ni.2959): LAT signalosome during TCR signaling. Bagalopalan, Journal of Biological Chemistry, 2015 (doi:10.1074/jbc.R115.665869): LAT signalosome. Papers: Liu, Current Biology, 1999 (doi:10.1016/S0960-9822(99)80017-7):LAT-GADS-SLP76 - In Jurkat and Raji cells. Su, European Journal of Immunology, 1999 (PMID:10556826): SLP76-ITK interaction. - In Jurkat T cells. Herndon, Journal of Immunology, 2001 (doi:10.4049/jimmunol.166.9.5654): LAT-SLP-76 regulate NFkB activation in response to TCR/CD28. - In Jurkat cell line. Hassan, Journal of Cellular Biology, 2006 (doi:10.1128/MCB.00688-06): CD6 costimulation requires SLP-76. - In Jurkat and Human primary T cells. Brainman, The EMBO Journal, 2006 (doi:10.1038/sj.emboj.7600978): Recruitment and activation of PLCg1. - In Jurkat cells and murine (C57BL/6) primary T cells. Bogin, PNAS, 2007 (doi:10.1073/pnas.0609771104): Itk is activated by its interaction with SLP76. - In The SLP-76-deficient Jurkat-derived cell line J14, and its WT SLP-76-reconstituted derivative, J14–76-11. Seet, The EMBO Journal, 2007 (doi:10.1038/sj.emboj.7601535): SLP76-GADS interaction. - In Jurkat T cells. Sylvain, Science Signaling, 2011 (doi:10.1126/scisignal.2001178): SLP-76 is stabilized by VAV1. - In Jurkat T cells. Shim, Journal of Immunology, 2011 (doi:10.4049/jimmunol.1001785): LAT and SLP76 are necesary for PI3K activation. - In Jurkat T cells (wt, J14 and JCam2). Cao, Plos One, 2012 (doi:10.1371/journal.pone.0046725): - In the Jurkat-derived cell line J14, reconstituited for SLP76 (J14-76-11). Roncagalli, Nature Immunology, 2014 (doi:10.1038/ni.2843): Proteomics of ZAP70. - In murine primary CD4 T cells. Bilal, Cellular Signaling, 2015 (doi:10.1016/j.cellsig.2015.01.012): GADS relevance for SLP76 and PLCg recruitment to LAT and Cytokine expression. - Human CD4 T cells. Breuning, Molecular and Cellular Biology, 2017, (doi: 10.1128/MCB.00071-17): CD6-GADS-SLP76. - In human primary CD4 T cells and Jurkat T cell line.

HGNC:2444 Reviews: Torgersen, The Journal of Biological Chemistry, 2001 (10.1074/jbc.C100014200): PAG regulates CSK during TCR signaling. Davidson, Mollecular And Cellular Biology, 2003 (10.1128/MCB.23.6.2017): PAG interacts with Csk to inhibit Lck activation. TCR ligation induces the disociation of PAG-Csk interaction and promotes T cell activation. Huang, Journal Of Biological Chemistry, 2004 (10.1074/jbc.R400012200): Review on TCR signaling. Salmond, Immunological Reviews, 2009 (10.1111/j.1600-065X.2008.00745.x): LCK and FYN function in TCR signaling to activate T Cells. Papers: Schoenborn, Sciensignaling, 2011 (10.1126/scisignal.2001893): LCK regulation by CD45 and CSK. Zhang, Molecular Cell, 2004 (doi:10.1016/S1097-2765(04)00050-4): SHP2 regulats CSK. - In 3T2 and 293 cell lines.

Reviews: Kim, Experimental and Molecular Medicine, 2000 (doi:10.1038/emm.2000.18): PLCg mechanism of action. Leo, Current Opinion In Immunology, 2002 (doi:10.1172/JCI200214942): DAG is necessary for PKCth(PRKCQ) activation. Saibil, Current Opinion in Immunology, 2007 (doi:10.1016/j.coi.2007.08.005): Anergy and Cell Cycle. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Stone, Genes and Cancer, 2011 (doi:10.1177/1947601911408082): RASGRP1 activation. Brownlie, Nature Reviews. Immunology, 2013 (doi:10.1038/nri3403): Review on TCR signaling. Jun, Frontiers in Immunology, 2013 (doi:10.3389/fimmu.2013.002399): Regulation of Ras activation. Krishna, Frontiers in Immunology, 2013 (doi:10.3389/fimmu.2013.00178): DGKs Riese, Frontiers in Cell and Developmental Biology, 2016 (doi:10.3389/fcell.2016.00108): DGKs Papers: Ebinu, BLOOD, 2000 (PMID: 10807788): RASGRP1 activation. - In Jurkat T cells.

HGNC:2857 HGNC:2849 Reviews: Saibil, Current Opinion in Immunology, 2007 (doi:10.1016/j.coi.2007.08.005): Anergy and Cell Cycle. Stone, Genes and Cancer, 2011 (doi:10.1177/1947601911408082): RASGRP1 activation. Riese, Frontiers in Cell and Developmental Biology, 2016 (doi:10.3389/fcell.2016.00108): DGKs Krishna, Frontiers in Immunology, 2013 (doi:10.3389/fimmu.2013.00178): DGKs

HGNC:6865 Reviews: Isakov, Frontiers In Immunology, 2012 (doi:10.3389/fimmu.2012.00273): Signals from CD28 to PKC theta. Chuang, Advances in Immunology, 2015 (doi:10.1016/bs.ai.2015.09.006): MAP4Ks in Immunity. Papers: Chuang, Nature Immunology, 2011 (doi:10.1038/ni.2121): GLK activates PKC theta (pThr538) directly to induce NFkB activation. - In Jurkat T cells.

HGNC:9410 Reviews: Coudronniere, PNAS, 2000 (doi:10.1073/pnas.060028097): TCR/CD28 activate NFkB through PKC theta Isakov, Annual Reviews. Immunology, 2002 (doi:10.1146/annurev.immunol.20.120701.074321): PKC theta in TCR/CD28 signaling. Huang, Journal Of Biological Chemistry, 2004 (doi:10.1074/jbc.R400012200): Review on TCR signaling. Schulze-Luehrmann, Immunity, 2006 (doi:10.1016/j.immuni.2006.10.010): TCR signaling to NFkB. Miller, Immunological Research, 2009 (doi:10.1007/s12026-009-8097-6): CD28 mediates PKCth recruitment to the immunological synapse. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Haubert, Cellular Signaling, 2010 (doi:10.1016/j.cellsig.2010.02.001): Vav1 signaling in TCR/CD28 stimulated T cells. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Blonska, Cell Research, 2011 (doi:10.1038/cr.2010.182): NFkB activation by CARMA. Isakov, Frontiers in Immunology, 2012 (doi:10.3389/fimmu.2012.00273): PKCtheta functions in TCR/CD28 signaling. Papers: Bauer, The Journal of Biological Chemistry, 2001 (doi:10.1074/jbc.M103098200): Akt and PKCtheta activation of NFkB. - In transfected Jurkat T cells. Herndon, Journal of Immunology, 2001 (doi:10.4049/jimmunol.166.9.5654): LAT-SLP-76 regulate NFkB activation in response to TCR/CD28. - In Jurkat cell line. Thebault, Molecular Immunology, 2003 (doi:10.1016/j.molimm.2003.10.014): TCR/CD28 activation of PKCtheta. Qiao, Molecular and Cellular Biology, 2008 (doi:10.1128/MCB.01505-07): CBLB regulation of NFkB activation. - In murine T cells. Chuang, Nature Immunology, 2011 (doi:10.1038/ni.2121): GLK activates PKC theta (pThr538) directly to induce NFkB activation. - In Jurkat T cells.

HGNC:14458 Reviews: Saito, Immunological Reviews, 2003 (PMID:12670402): Negatve feedback of T cell activation. Bartelt, Wiley interdisciplinary reviews. Systems biology and medicine, 2013 (doi:10.1002/wsbm.1194): LAT integrate signals from TCR. Papers: Yamasaki, Journal of Biological Chemistry, 2001 (doi:10.1074/jbc.M105384200): GAB2 recruitment and activation. - In T cell lines: 21-1-8, Jurkat and 2B4. Yamasaki, Mollecular And Cellular Biology, 2003 (doi:10.1128/MCB.23.7.2515): GAB2 interacts with GRAP2 and GRB2 for inhibiting TCR signals. - Jurkat T, Jurkat J.EcoR cells, LAT-deficient Jurkat cell line J.CaM2.5, and SLP- 76-deficient Jurkat cell line J.14. Arnaud, , 2004 (doi:10.1042/BJ20040103): GAB2-SHP2 interaction.

HGNC:4563 Reviews: Leo, Current Opinion In Immunology, 2002 (doi:10.1172/JCI200214942): LCP2(SLP76) is recruited to LAT through GADS(GRAP2), where it is phosphorylated. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Bartelt, Wiley interdisciplinary reviews. Systems biology and medicine, 2013 (doi:10.1002/wsbm.1194): LAT integrate signals from TCR. Roncagalli, Nature Immunology, 2014 (10.1038/ni.2843): GADS interacts constitutively with SLP76. Malissen, Nature Immunology, 2014 (doi:10.1038/ni.2959): LAT signalosome during TCR signaling. Bagalopalan, Journal of Biological Chemistry, 2015 (doi:10.1074/jbc.R115.665869): LAT signalosome. Papers: Liu, Current Biology, 1999 (10.1016/S0960-9822(99)80017-7):LAT-GADS-SLP76 - In Jurkat and Raji cells. Zhang, The Journal of Biological Chemistry, 2000 (doi:10.1074/jbc.M000404200): GRB2, GADS y PLC gamma 1 are recruited to phosphorylated LAT. - In Jurkat cells (E6.1) and LAT-deficient cells (J.CaM2.5). Yamasaki, Mollecular And Cellular Biology, 2003 (doi:10.1128/MCB.23.7.2515): GAB2 interacts with GRAP2 and GRB2 for inhibiting TCR signals. - Jurkat T, Jurkat J.EcoR cells, LAT-deficient Jurkat cell line J.CaM2.5, and SLP- 76-deficient Jurkat cell line J.14. Seet, The EMBO Journal, 2007 (doi:10.1038/sj.emboj.7601535): SLP76-GADS interaction. - In Jurkat T cells. Bilal, Cellular Signaling, 2015 (doi:10.1016/j.cellsig.2015.01.012): GADS relevance for SLP76 and PLCg recruitment to LAT and Cytokine expression. - Human CD4 T cells.

HGNC:9871

HGNC:12657 Reviews: Leo, Current Opinion In Immunology, 2002 (doi:10.1172/JCI200214942): Grb2-Sos complex is recruited to phosphorylated LAT. Tybulewicz, Current Opinion in Immunology, 2005 (doi:10.1016/j.coi.2005.04.003): Review on VAV proteins. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Kannan, The International Journal of Biochemistry and Cell Biology, 2012 (doi:10.1016/j.biocel.2012.08.023): TCR signaling review. Brownlie, Nature Reviews. Immunology, 2013 (doi:10.1038/nri3403): Review on TCR signaling. Matalon, Immunological Reviews, 2013 (doi:10.1111/imr.12112): Actin remodeling Bagalopalan, Journal of Biological Chemistry, 2015 (doi:10.1074/jbc.R115.665869): LAT signalosome. Papers: Deckert, Immunity, 1998 (doi:10.1016/S1074-7613(00)80657-3): 3BP2 functions. - In Jurkat-TAg cells, Wild-type Jurkat (clone E6.1), CEM, HUT-78, Raji, U937, Jurkat cells lacking Zap-70 (P116), murine CD4+ DBHy3 and CD8+ B3Z T cell hybridomas. Salojin, Journal of Immunology, 1999 (PMID: 10395678): TCR and CD28 are coupled through Zap70 to the activation of Vav-Rac1-p38 pathway. - In Lck-negative JCaM1.6 cells, the human Jurkat cell line E6.1, P116 ZAP-70-deficient cell line (a variant of the Jurkat E6.1 T cell line), the EL4 mouse T cell line and CHO cells. Michel, The journal of Immunology, 2000 (doi:10.4049/jimmunol.165.7.3820): CD28 co-estimulatory signals require VAV1. - In Jurkat T cells and derivatives. Herndon, Journal of Immunology, 2001 (doi:10.4049/jimmunol.166.9.5654): LAT-SLP-76 regulate NFkB activation in response to TCR/CD28. - In Jurkat cell line. Tartare-Deckert, Journal of Biological Chemistry, 2001 (doi:10.1074/jbc.M010588200): Vav2 and Vav1 activate c-Fos Serum Response Element. - In Simian virus 40 T antigen-transfected human leukemic Jurkat T cells (Jurkat-TAg) and Jurkat clone JE6.1. Reynolds, The Journal of Experimental Medicine, 2002 (doi:10.1084/jem.20011663): Vav1 functios in TCR signaling. - In mouse thymocytes. Reynolds, The Journal of Biological chemistry, 2004 (doi:10.1074/jbc.M400257200): Vav1 functions in TCR signaling. - In mouse thymocites Charvet, The Journal of Biological Chemistry, 2002 (doi:10.1074/jbc.M111627200): VAV1 and VAV2 mediate SRF activation and c-FOS expresion through RAC1/CDC42 pathways. - In Jurkat T cells (clone JE6.1), and simian virus 40 T antigen-transfected human leukemic Jurkat T cells (Jurkat-TAg). Labno, Current Biology, 2003 (doi:10.1016/j.cub.2003.08.005): Itk role in Actin remodeling. - In primary T cell blasts from wild-type (wt), Itk-/-, Rlk-/-,or Rlk-/- Itk-/- TCR transgenic mice. Foucault, BLOOD, 2005 (doi:10.1182/blood-2003-08-2965):3BP2 intracts with Vav and regulates NFAT activation: - In the human B (BJAB, RPMI8866, Daudi, and Raji) and T (Jurkat) cell lines. Sylvain, Science Signaling, 2011 (doi:10.1126/scisignal.2001178): SLP-76 is stabilized by VAV1. - In Jurkat T cells.

HGNC:12658 Papers: Tartare-Deckert, Journal of Biological Chemistry, 2001 (doi:10.1074/jbc.M010588200): Vav2 and Vav1 activate c-Fos Serum Response Element. - In Simian virus 40 T antigen-transfected human leukemic Jurkat T cells (Jurkat-TAg) and Jurkat clone JE6.1. Charvet, The Journal of Biological Chemistry, 2002 (doi:10.1074/jbc.M111627200): VAV1 and VAV2 mediate SRF activation and c-FOS expresion through RAC1/CDC42 pathways. - In Jurkat T cells (clone JE6.1), and simian virus 40 T antigen-transfected human leukemic Jurkat T cells (Jurkat-TAg). Foucault, BLOOD,2005 (doi:10.1182/blood-2003-08-2965):3BP2 intracts with Vav and regulates NFAT activation: - In the human B (BJAB, RPMI8866, Daudi, and Raji) and T (Jurkat) cell lines.

HGNC:4566 Reviews: Zhang, The Journal of Biological Chemistry, 2000 (doi:10.1074/jbc.M000404200): GRB2, GADS y PLC gamma 1 are recruited to phosphorylated LAT. Leo, Current Opinion In Immunology, 2002 (doi:10.1172/JCI200214942): Grb2-Sos complex is recruited to phosphorylated LAT. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Bartelt, Wiley interdisciplinary reviews. Systems biology and medicine, 2013 (doi:10.1002/wsbm.1194): LAT integrate signals from TCR. Jun, Frontiers in Immunology, 2013 (doi:10.3389/fimmu.2013.002399): Regulation of Ras activation. Malissen, Nature Immunology, 2015 (doi:10.1038/ni.2959): LAT signalosome during TCR signaling. Bagalopalan, Journal of Biological Chemistry, 2015 (doi:10.1074/jbc.R115.665869): LAT signalosome. Papers: Kim, Journal of Biological Chemistry, 1998 (10.1074/jbc.273.1.296): Grb2 interaction with CD28 and its role in costimulation. - In the murine T cell hybridoma DC27.10, CHO cells, and CHO-CD86 cells. Zhang, The Journal of Biological Chemistry, 2000 (doi:10.1074/jbc.M000404200): GRB2, GADS y PLC gamma 1 are recruited to phosphorylated LAT. - In Jurkat cells (E6.1) and LAT-deficient cells (J.CaM2.5). Yamasaki, Mollecular And Cellular Biology, 2003 (doi:10.1128/MCB.23.7.2515): GAB2 interacts with GRAP2 and GRB2 for inhibiting TCR signals. - Jurkat T, Jurkat J.EcoR cells, LAT-deficient Jurkat cell line J.CaM2.5, and SLP- 76-deficient Jurkat cell line J.14. Kortum, Science Signaling, 2013 (doi:10.1126/scisignal.2004494): SOS1 ability to oligomerize with LAT. - In DP thymocites. Higo, Immunological Investigations, 2014 (doi:10.3109/08820139.2013.875039): CD28-GADS interaction. - Isolated proteins.

HGNC:11187 Reviews: Leo, Current Opinion In Immunology, 2002 (doi:10.1172/JCI200214942): Grb2-Sos complex is recruited to phosphorylated LAT. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Bartelt, Wiley interdisciplinary reviews. Systems biology and medicine, 2013 (doi:10.1002/wsbm.1194): LAT integrate signals from TCR. Jun, Frontiers in Immunology, 2013 (doi:10.3389/fimmu.2013.002399): Regulation of Ras activation. Bagalopalan, Journal of Biological Chemistry, 2015 (doi:10.1074/jbc.R115.665869): LAT signalosome. Papers: Salojin, Journal of Immunology, 1999 (PMID: 10395678): TCR and CD28 are coupled through Zap70 to the activation of Vav-Rac1-p38 pathway. - In Lck-negative JCaM1.6 cells, the human Jurkat cell line E6.1, P116 ZAP-70-deficient cell line (a variant of the Jurkat E6.1 T cell line), the EL4 mouse T cell line and CHO cells. Zhang, The Journal of Biological Chemistry, 2000 (doi:10.1074/jbc.M000404200): GRB2, GADS y PLC gamma 1 are recruited to phosphorylated LAT. - In Jurkat cells (E6.1) and LAT-deficient cells (J.CaM2.5). Kortum, Science Signaling, 2013 (doi:10.1126/scisignal.2004494): SOS1 ability to oligomerize with LAT. - In DP thymocites.

HGNC:4617 Reviews: Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Hemmings, Cold Spring Harbor Perspectives in Biology, 2012 (doi:10.1101/cshperspect.a011189): PI3K pathway. Newton, Frontiers in Immunology, 2012 (doi:10.3389/fimmu.2012.00151): PTEN in T cells. Okkenhaug, Annual Reviews. Immunology, 2013 (doi:10.1146/annurev-immunol-032712-095946): Signaling by PI3K. Hermida, Advances in Biological Regulation, 2017 (doi:10.1016/j.jbior.2017.06.003): GSK3b functions. Papers: Appleman, Journal of Immunology, 2002, (doi:10.4049/jimmunol.168.6.2729): CD28 and TCR signals mediate PI3K activation and Cell Cycle progression. - In human primary T cells. Gotschel, Experimental Cell Research, 2008 (doi:10.1016/j.yexcr.2007.12.015): - In mouse hepatocytes.

HGNC:6863 Reviews: Chuang, Advances in Immunology, 2015 (doi:10.1016/bs.ai.2015.09.006): MAP4Ks in Immunity.

HGNC:4095 Reviews: Rudd, Nature Immunoogy, 2005 (doi:10.1038/ni0405-368): Pathways of P38a activation in T cells. Papers: Salvador, Nature Immunology, 2005 (doi:10.1038/ni1176): P38 pathway mediated by ZAP70. - In murine CD4 and CD8 T cells.

HGNC:7797 Reviews: Isakov, Annual Reviews. Immunology, 2002 (doi:10.1146/annurev.immunol.20.120701.074321): PKC theta in TCR/CD28 signaling. Schulze-Luehrmann, Immunity, 2006 (doi:10.1016/j.immuni.2006.10.010): TCR signaling to NFkB. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Papers: Bauer, The Journal of Biological Chemistry, 2001 (doi:10.1074/jbc.M103098200): Akt and PKCtheta activation of NFkB. - In transfected Jurkat T cells.

HGNC:5960 HGNC:1974 Reviews: Isakov, Annual Reviews. Immunology, 2002 (doi:10.1146/annurev.immunol.20.120701.074321): PKC theta in TCR/CD28 signaling. Schulze-Luehrmann, Immunity, 2006 (doi:10.1016/j.immuni.2006.10.010): TCR signaling to NFkB. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Indirect. Blonska, Cell Research, 2011 (doi:10.1038/cr.2010.182): NFkB activation by CARMA. Lupino, The Journal Immunology, 2012 (doi:10.4049/jimmunol.1102938): IKK activation during TCR/CD28 signaling. Hemmings, Cold Spring Harbor Perspectives in Biology, 2012 (doi:10.1101/cshperspect.a011189): PI3K pathway. Papers: Bauer, The Journal of Biological Chemistry, 2001 (doi:10.1074/jbc.M103098200): Akt and PKCtheta activation of NFkB. - In transfected Jurkat T cells. Cheng, The Journal of Biological Chemistry (doi:10.1074/jbc.M111.259549): Role of Akt in NFkB-dependent transcriptional regulation. - In D10 Tcell clone and cD4 T cells from DO11.10 TCR transgenic mice.

HGNC:5961 Reviews: Schulze-Luehrmann, Immunity, 2006 (doi:10.1016/j.immuni.2006.10.010): TCR signaling to NFkB. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Blonska, Cell Research, 2011 (doi:10.1038/cr.2010.182): NFkB activation by CARMA. Kannan, The International Journal of Biochemistry and Cell Biology, 2012 (doi:10.1016/j.biocel.2012.08.023): TCR signaling review.

Reviews: Kim, Experimental and Molecular Medicine, 2000 (doi:10.1038/emm.2000.18): PLCg mechanism of action. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Bartelt, Wiley interdisciplinary reviews. Systems biology and medicine, 2013 (doi:10.1002/wsbm.1194): LAT integrate signals from TCR.

HGNC:6171 Reviews: Schaeffer, Current Opinion In Immunology, 2000 (doi:10.1016/S0952-7915(00)00088-1): Lck phosphorylates Itk and Rlk, and they phosphorylate and activates PLCg. Itk requires PIP3. ZAP70 indirectly mediates Itk phosphorylation. Rlk phosphorylates SLP76. Kane, Current Opinion in Immunology, 2000 (doi:10.1016/S0952-7915(00)00083-2): TCR signaling review. August, International Journal of Biochemistry, 2002 (doi:10.1016/S1357-2725(02)00068-7): Lck phosphorylates and activates ZAP70, Itk and Rlk. Zap70 phosphorylates LAT and SLP76. Itk and Rlk phosphorylate PLCg. Okkenhaug, Biochemical Society Transactions, 2004 (doi:10.1042/bst0320332): PI3K role in T cell activation. Berg, Annual Review of Immunology, 2005 (doi:10.1146/annurev.immunol.22.012703.104743): Review on Tec kinases. Schwartzberg, Nature Reviews Immunology, 2005 (doi:10.1038/nri1591): Review on Tec kinases Schulze-Luehrmann, Immunity, 2006 (doi:10.1016/j.immuni.2006.10.010): TCR signaling to NFkB. Qi, Science's STKE : signal transduction knowledge environment, 2007 (doi:10.1126/stke.3962007pe39): On SLP-76 - ITK interaction. Felices, Advances In Immunology, 2007 (doi:10.1016/S0065-2776(06)93004-1): Itk and Rlk phosphorylate PLCg with the requirement of LAT-SLP76. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Readinger, Immunological Reviews, 2009 (doi:10.1111/j.1600-065X.2008.00757.x): Review on Tec kinases. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Grasis, Journal of Signalm Transduction, 2011 (doi:10.1155/2011/297868): Review on ITK. Kannan, The International Journal of Biochemistry and Cell Biology, 2012 (doi:10.1016/j.biocel.2012.08.023): TCR signaling review. August, International Reviews of Immunology, 2012 (doi:10.3109/08830185.2012.668981): Itk function in TCR signaling. Brownlie, Nature Reviews. Immunology, 2013 (doi:10.1038/nri3403): Review on TCR signaling. Bartelt, Wiley interdisciplinary reviews. Systems biology and medicine, 2013 (doi:10.1002/wsbm.1194): LAT integrate signals from TCR. Papers: Su, European Journal of Immunology, 1999 (PMID:10556826): SLP76-ITK interaction. - In Jurkat T cells. Schaeffer, Science, 1999 (doi:10.1126/science.284.5414.638):Itk and Rlk roles in TCR signaling. - In murine T cells. Labno, Current Biology, 2003 (doi:10.1016/j.cub.2003.08.005): Itk role in Actin remodeling. - In primary T cell blasts from wild-type (wt), Itk-/-, Rlk-/-,or Rlk-/- Itk-/- TCR transgenic mice. Bogin, PNAS, 2007 (doi:10.1073/pnas.0609771104): Itk is activated by its interaction with SLP76. - In The SLP-76-deficient Jurkat-derived cell line J14, and its WT SLP-76-reconstituted derivative, J14–76-11. Min, PNAS, 2009 (doi:10.1073/pnas.0911309106): ITK-PLCg interaction. - In Jurkat Jg1 cells.

Reviews: Schulze-Luehrmann, Immunity, 2006 (doi:10.1016/j.immuni.2006.10.010): TCR signaling to NFkB. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Blonska, Cell Research, 2011 (doi:10.1038/cr.2010.182): NFkB activation by CARMA. Papers:

HGNC:6840 HGNC:6842 Reviews: Dong, Annual Review of Immunology, 2002 (doi:10.1146/annurev.immunol.20.091301.131133): MAP kinases in immune response. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Meng, Protein and Cell, 2011 (doi:10.1007/s13238-011-1113-3):Review of cJun. Papers: Appleman, Journal of Immunology, 2002, (doi:10.4049/jimmunol.168.6.2729): CD28 and TCR signals mediate PI3K activation and Cell Cycle progression. - In human primary T cells. Charvet, The Journal of Biological Chemistry, 2002 (doi:10.1074/jbc.M111627200): VAV1 and VAV2 mediate SRF activation and c-FOS expresion through RAC1/CDC42 pathways. - In Jurkat T cells (clone JE6.1), and simian virus 40 T antigen-transfected human leukemic Jurkat T cells (Jurkat-TAg). Reynolds, The Journal of Biological chemistry, 2004 (doi:10.1074/jbc.M400257200): Vav1 functions in TCR signaling. - In mouse thymocites

HGNC:6848 Reviews: Symons, TRENDs in Immunology, 2006 (10.1016/j.it.2005.11.007): MLK3 promotes JNK activation in Jurka T cells. Chuang, Advances in Immunology, 2015 (doi:10.1016/bs.ai.2015.09.006): MAP4Ks in Immunity.

HGNC:6844 Reviews: Dong, Annual Review of Immunology, 2002 (doi:10.1146/annurev.immunol.20.091301.131133): MAP kinases in immune response. Cuenda, The International Journal of Biochemistry and Cell Biology, 2002 (PMID:10785355): MKK4 activates JNK. Symons, TRENDs in Immunology, 2006 (10.1016/j.it.2005.11.007): MLK3 promotes JNK activation in Jurka T cells. Meng, Protein and Cell, 2011 (doi:10.1007/s13238-011-1113-3):Review of cJun. Chuang, Advances in Immunology, 2015 (doi:10.1016/bs.ai.2015.09.006): MAP4Ks in Immunity.

HGNC:6850 Reviews: Symons, TRENDs in Immunology, 2006 (10.1016/j.it.2005.11.007): MLK3 promotes JNK activation in Jurka T cells. Chuang, Advances in Immunology, 2015 (doi:10.1016/bs.ai.2015.09.006): MAP4Ks in Immunity.

HGNC:8816 Reviews: Vanhaesebroeck, the Biochemical Journal, 2000 (doi:10.1042/0264-6021:3460561): PI3K, PDK, and Akt activation. Bauer, Molecular Immunology, 2002 (doi:10.1016/S0161-5890(02)00011-1): PKC and Akt are partners in TCR/CD28 signaling. Schulze-Luehrmann, Immunity, 2006 (doi:10.1016/j.immuni.2006.10.010): TCR signaling to NFkB. Saibil, Current Opinion in Immunology, 2007 (doi:10.1016/j.coi.2007.08.005): Anergy and Cell Cycle. Buckler, Immunological Reviews, 2008 (doi:10.1111/j.1600-065X.2008.00650.x): Regulation of T cell responses by PTEN. Takada, Nature Reviews. Immunology, 2009 (doi:10.1038/nri2657): T cell homeostasis. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Kannan, The International Journal of Biochemistry and Cell Biology, 2012 (doi:10.1016/j.biocel.2012.08.023): TCR signaling review. Hemmings, Cold Spring Harbor Perspectives in Biology, 2012 (doi:10.1101/cshperspect.a011189): PI3K pathway. Newton, Frontiers in Immunology, 2012 (doi:10.3389/fimmu.2012.00151): PTEN in T cells. Gamper, Frontiers in Immunology, 2012 (doi:10.3389/fimmu.2012.00312): PI3K, mTOR-dependent and -independent pathways. Okkenhaug, Annual Reviews. Immunology, 2013 (doi:10.1146/annurev-immunol-032712-095946): Signaling by PI3K. Papers: Thebault, Molecular Immunology, 2003 (doi:10.1016/j.molimm.2003.10.014): TCR/CD28 activation of PKCtheta. - In primary murine T cells, DPK cell line, DCEK-ICAM cell line, Jurkat (E6.1) cell line and 298T cell line.

HGNC:8979 Reviews: Samstag, Advances in Enzime Regulation, 2005 (doi:10.1016/j.advenzreg.2005.02.005): PI3K activation by TCR and CD28. Schulze-Luehrmann, Immunity, 2006 (doi:10.1016/j.immuni.2006.10.010): TCR signaling to NFkB. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Kannan, The International Journal of Biochemistry and Cell Biology, 2012 (doi:10.1016/j.biocel.2012.08.023): TCR signaling review. Isakov, Frontiers In Immunology, 2012 (doi:10.3389/fimmu.2012.00273): Signals from CD28 to PKC theta. Gamper, Frontiers in Immunology, 2012 (10.3389/fimmu.2012.00312): PI3K, mTOR-dependent and -independent pathways. Bartelt, Wiley interdisciplinary reviews. Systems biology and medicine, 2013 (doi:10.1002/wsbm.1194): LAT integrate signals from TCR. Okkenhaug, Annual Reviews. Immunology, 2013 (doi:10.1146/annurev-immunol-032712-095946): Signaling by PI3K. Chen, Nature Reviews. Immunology, 2013 (doi:10.1038/nri3405): Co-signaling receptors. Papers: Shim, Journal of Immunology, 2011 (doi:10.4049/jimmunol.1001785): LAT and SLP76 are necesary for PI3K activation. - In Jurkat T cells (wt, J14 and JCam2).

Reviews: Vanhaesebroeck, the Biochemical Journal, 2000 (doi:10.1042/0264-6021:3460561): PI3K, PDK, and Akt activation. Okkenhaug, Biochemical Society Transactions, 2004: PI3K role in T cell activation. Schulze-Luehrmann, Immunity, 2006 (doi:10.1016/j.immuni.2006.10.010): TCR signaling to NFkB. Gloire, Biochemical Society Transactions, 2007 (doi: 10.1042/BST035027710.1042/BST0350277): Review on SHIP-1. Buckler, Immunological Reviews, 2008 (doi:10.1111/j.1600-065X.2008.00650.x): Regulation of T cell responses by PTEN. Takada, Nature Reviews. Immunology, 2009 (doi:10.1038/nri2657): T cell homeostasis. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Parry, Biochimica et Biophysica Acta, 2010 (doi:10.1016/j.bbapap.2009.09.019): Review on SHIP-1. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Kannan, The International Journal of Biochemistry and Cell Biology, 2012 (doi:10.1016/j.biocel.2012.08.023): TCR signaling review. Newton, Frontiers in Immunology, 2012 (doi:10.3389/fimmu.2012.00151): PTEN in T cells. Gamper, Frontiers in Immunology, 2012 (doi:10.3389/fimmu.2012.00312): PI3K, mTOR-dependent and -independent pathways. Bartelt, Wiley interdisciplinary reviews. Systems biology and medicine, 2013 (doi:10.1002/wsbm.1194): LAT integrate signals from TCR. Okkenhaug, Annual Reviews. Immunology, 2013 (doi:10.1146/annurev-immunol-032712-095946): Signaling by PI3K. Hermida, Advances in Biological Regulation, 2017 (doi:10.1016/j.jbior.2017.06.003): GSK3b functions. Papers: Michel, The journal of Immunology, 2000 (doi:10.4049/jimmunol.165.7.3820): CD28 co-estimulatory signals require VAV1. - In Jurkat T cells and derivatives. Harriague, Nature Immunology, 2002 (doi:10.1038/ni847): PIP3 generation at the Immunological synapse. - In T8 cell lina and Human CD4 T cells. Thebault, Molecular Immunology, 2003 (doi:10.1016/j.molimm.2003.10.014): TCR/CD28 activation of PKCtheta. - In primary murine T cells, DPK cell line, DCEK-ICAM cell line, Jurkat (E6.1) cell line and 298T cell line. Buckler, Journal of Immunology, 2006, (doi:10.4049/jimmunol.177.7.4262): PTEN imposes a requirement of CD28 costimulation for the induction of the PI3K pathway. - In murine (OT-II) primary CD4 T cells. Garcon, Blood, 2008 (doi:10.1182/blood-2007-08-108050): CD28 costimulation. - In murin (OT-II T-cell) primary CD4 T cells. Shim, Journal of Immunology, 2011 (doi:10.4049/jimmunol.1001785): LAT and SLP76 are necesary for PI3K activation. - In Jurkat T cells (wt, J14 and JCam2).

HGNC:391 HGNC:392 Reviews: Vanhaesebroeck, the Biochemical Journal, 2000 (doi:10.1042/0264-6021:3460561): PI3K, PDK, and Akt activation. Bauer, Molecular Immunology, 2002 (doi:10.1016/S0161-5890(02)00011-1): PKC and Akt are partners in TCR/CD28 signaling. Isakov, Annual Reviews. Immunology, 2002 (doi:10.1146/annurev.immunol.20.120701.074321): PKC theta in TCR/CD28 signaling. Schulze-Luehrmann, Immunity, 2006 (doi:10.1016/j.immuni.2006.10.010): TCR signaling to NFkB. Saibil, Current Opinion in Immunology, 2007 (doi:10.1016/j.coi.2007.08.005): Anergy and Cell Cycle. Takada, Nature Reviews. Immunology, 2009 (doi:10.1038/nri2657): T cell homeostasis. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Miller, Immunological Research, 2009 (doi:10.1007/s12026-009-8097-6): CD28 mediates PKCth recruitment to the immunological synapse. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Waickman, Immunological Reviews, 2012 (doi:10.1111/j.1600-065X.2012.01152.x): mTOR/Akt pathway. Hemmings, Cold Spring Harbor Perspectives in Biology, 2012 (doi:10.1101/cshperspect.a011189): PI3K pathway. Newton, Frontiers in Immunology, 2012 (doi:10.3389/fimmu.2012.00151): PTEN in T cells. Gamper, Frontiers in Immunology, 2012 (doi:10.3389/fimmu.2012.00312): PI3K, mTOR-dependent and -independent pathways. Chen, Nature Reviews. Immunology, 2013 (doi:10.1038/nri3405): Co-signaling receptors. Okkenhaug, Annual Reviews. Immunology, 2013 (doi:10.1146/annurev-immunol-032712-095946): Signaling by PI3K. Hermida, Advances in Biological Regulation, 2017 (doi:10.1016/j.jbior.2017.06.003): GSK3b functions. Papers: Bauer, The Journal of Biological Chemistry, 2001 (doi:10.1074/jbc.M103098200): Akt and PKCtheta activation of NFkB. - In transfected Jurkat T cells. Appleman, Journal of Immunology, 2002, (doi:10.4049/jimmunol.168.6.2729): CD28 and TCR signals mediate PI3K activation and Cell Cycle progression. - In human primary T cells. Thebault, Molecular Immunology, 2003 (doi:10.1016/j.molimm.2003.10.014): TCR/CD28 activation of PKCtheta. - In primary murine T cells, DPK cell line, DCEK-ICAM cell line, Jurkat (E6.1) cell line and 298T cell line. Sauer, PNAS, 2008 (doi:10.1073/pnas.0800928105): TCR/CD28 activate PI3K/Akt/mTOR pathway to induce FoxP3 expression. - In murine transgenic CD4 T cells. Cheng, The Journal of Biological Chemistry (doi:10.1074/jbc.M111.259549): Role of Akt in NFkB-dependent transcriptional regulation. - In D10 Tcell clone and cD4 T cells from DO11.10 TCR transgenic mice. Shim, Journal of Immunology, 2011 (doi:10.4049/jimmunol.1001785): LAT and SLP76 are necesary for PI3K activation. - In Jurkat T cells (wt, J14 and JCam2). Ouyang, Nature, 2012 (doi:10.1038/nature11581): Foxo1-dependent transcriptional programs. - Mouse mutant T reg cells.

HGNC:9065 Reviews: Kim, Experimental and Molecular Medicine, 2000 (doi:10.1038/emm.2000.18): PLCg mechanism of action. Schaeffer, Current Opinion In Immunology, 2000 (doi:10.1016/S0952-7915(00)00088-1): Lck phosphorylates Itk and Rlk, and they phosphorylate and activates PLCg. Itk requires PIP3. ZAP70 indirectly mediates Itk phosphorylation. Rlk phosphorylates SLP76. Leo, Current Opinion In Immunology, 2002 (doi:10.1172/JCI200214942): LCP2(SLP76) is recruited to LAT through GADS(GRAP2), where it is phosphorylated. August, The Journal Of Biochemistry And Celullar Biology, 2002 (doi:10.1016/S1357-2725(02)00068-7): Lck phosphorylates and activates ZAP70, Itk and Rlk. Zap70 phosphorylates LAT and SLP76. Itk and Rlk phosphorylate PLCg. Huang, Journal Of Biological Chemistry, 2004 (doi:10.1074/jbc.R400012200): Review on TCR signaling. Schulze-Luehrmann, Immunity, 2006 (doi:10.1016/j.immuni.2006.10.010): TCR signaling to NFkB. Felices, Advances In Immunology, 2007 (doi:10.1016/S0065-2776(06)93004-1): Itk and Rlk phosphorylate PLCg with the requirement of LAT-SLP76. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Readinger, Immunological Reviews, 2009 (doi:10.1111/j.1600-065X.2008.00757.x): Review on Tec kinases. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Kannan, The International Journal of Biochemistry and Cell Biology, 2012 (doi:10.1016/j.biocel.2012.08.023): TCR signaling review. Brownlie, Nature Reviews. Immunology, 2013 (doi:10.1038/nri3403): Review on TCR signaling. Bartelt, Wiley interdisciplinary reviews. Systems biology and medicine, 2013 (doi:10.1002/wsbm.1194): LAT integrate signals from TCR. Bagalopalan, Journal of Biological Chemistry, 2015 (doi:10.1074/jbc.R115.665869): LAT signalosome. Papers: Schaefer, Science, 1999 (doi:10.1126/science.284.5414.638):Itk and Rlk roles in TCR signaling. - In murine T cells. Williams, The EMBO Journal, 1999 (doi:10.1093/emboj/18.7.1832): Tyr319 phosphorylation is important for ZAP70 mediated Ras and PLCg activation. Ebinu, BLOOD, 2000 (PMID: 10807788): RASGRP1 activation. - In Jurkat T cells. Zhang, The Journal of Biological Chemistry, 2000 (doi:10.1074/jbc.M000404200): GRB2, GADS y PLC gamma 1 are recruited to phosphorylated LAT. - In Jurkat cells (E6.1) and LAT-deficient cells (J.CaM2.5). Brainman, The EMBO Journal, 2006 (doi:10.1038/sj.emboj.7600978): Recruitment and activation of PLCg1. - In Jurkat cells and murine (C57BL/6) primary T cells. Bogin, PNAS, 2007 (doi:10.1073/pnas.0609771104): Itk is activated by its interaction with SLP76. - In The SLP-76-deficient Jurkat-derived cell line J14, and its WT SLP-76-reconstituted derivative, J14–76-11. Min, PNAS, 2009 (doi:10.1073/pnas.0911309106): ITK-PLCg interaction. - In Jurkat Jg1 cells. Bilal, Cellular Signaling, 2015 (doi:10.1016/j.cellsig.2015.01.012): GADS relevance for SLP76 and PLCg recruitment to LAT and Cytokine expression. - Human CD4 T cells.

HGNC:2579 Papers: Gotschel, Experimental Cell Research, 2008 (doi:10.1016/j.yexcr.2007.12.015):GSK3b regulates inhibitoon b-Catenin, AP-1 and CREB. - In mouse hepatocytes.

HGNC:3819 Reviews: Vanhaesebroeck, the Biochemical Journal, 2000 (doi:10.1042/0264-6021:3460561): PI3K, PDK, and Akt activation. Bauer, Molecular Immunology, 2002 (doi:10.1016/S0161-5890(02)00011-1): PKC and Akt are partners in TCR/CD28 signaling. Takada, Nature Reviews. Immunology, 2009 (doi:10.1038/nri2657): T cell homeostasis. Hemmings, Cold Spring Harbor Perspectives in Biology, 2012 (doi:10.1101/cshperspect.a011189): PI3K pathway. Newton, Frontiers in Immunology, 2012 (doi:10.3389/fimmu.2012.00151): PTEN in T cells. Gamper, Frontiers in Immunology, 2012 (doi:10.3389/fimmu.2012.00312): PI3K, mTOR-dependent and -independent pathways. Okkenhaug, Annual Reviews. Immunology, 2013 (doi:10.1146/annurev-immunol-032712-095946): Signaling by PI3K. Hermida, Advances in Biological Regulation, 2017 (doi:10.1016/j.jbior.2017.06.003): GSK3b functions. Papers: Appleman, Journal of Immunology, 2002, (doi:10.4049/jimmunol.168.6.2729): CD28 and TCR signals mediate PI3K activation and Cell Cycle progression. - In human primary T cells. Ouyang, Nature, 2012 (doi:10.1038/nature11581): Foxo1-dependent transcriptional programs. - Mouse mutant T reg cells.

HGNC:1785 Reviews: Vanhaesebroeck, the Biochemical Journal, 2000 (doi:10.1042/0264-6021:3460561): PI3K, PDK, and Akt activation. Bauer, Molecular Immunology, 2002 (doi:10.1016/S0161-5890(02)00011-1): PKC and Akt are partners in TCR/CD28 signaling. Saibil, Current Opinion in Immunology, 2007 (doi:10.1016/j.coi.2007.08.005): Anergy and Cell Cycle. Takada, Nature Reviews. Immunology, 2009 (doi:10.1038/nri2657): T cell homeostasis. Hemmings, Cold Spring Harbor Perspectives in Biology, 2012 (doi:10.1101/cshperspect.a011189): PI3K pathway. Newton, Frontiers in Immunology, 2012 (doi:10.3389/fimmu.2012.00151): PTEN in T cells. Papers: Appleman, Journal of Immunology, 2002, (doi:10.4049/jimmunol.168.6.2729): CD28 and TCR signals mediate PI3K activation and Cell Cycle progression. - In human primary T cells.

HGNC:1784 Reviews: Hemmings, Cold Spring Harbor Perspectives in Biology, 2012 (doi:10.1101/cshperspect.a011189): PI3K pathway. Papers: Ouyang, Nature, 2012 (doi:10.1038/nature11581): Foxo1-dependent transcriptional programs. - Mouse mutant T reg cells.

HGNC:992 Reviews: Vanhaesebroeck, the Biochemical Journal, 2000 (doi:10.1042/0264-6021:3460561): PI3K, PDK, and Akt activation. Bauer, Molecular Immunology, 2002 (doi:10.1016/S0161-5890(02)00011-1): PKC and Akt are partners in TCR/CD28 signaling. Isakov, Annual Reviews. Immunology, 2002 (doi:10.1146/annurev.immunol.20.120701.074321): Akt inhibits BAD and apoptosis. Okkenhaug, Biochemical Society Transactions, 2004 (doi:10.1042/): PI3K role in T cell activation. Takada, Nature Reviews. Immunology, 2009 (doi:10.1038/nri2657): T cell homeostasis. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Newton, Frontiers in Immunology, 2012 (doi:10.3389/fimmu.2012.00151): PTEN in T cells. Chen, Nature Reviews. Immunology, 2013 (doi:10.1038/nri3405): Co-signaling receptors.

HGNC:21166 Gamper, Frontiers in Immunology, 2012 (10.3389/fimmu.2012.00312): PI3K, mTOR-dependent and -independent pathways. Okkenhaug, Annual Reviews. Immunology, 2013 (doi:10.1146/annurev-immunol-032712-095946): Signaling by PI3K. Indirect.

HGNC:1542 Reviews: Thien, Biochemical Journal, 2005 (doi:10.1042/BJ20050892): CCBL and CBLB regulation. Schmitz, Science Signaling, 2009 (doi:10.1126/scisignal.276pe38): CBLB in T cells. Papers: Fang, Nature Immunology, 2001 (doi:10.1038/ni0901-870): CBLB inhibits p85. - In Jurkat T cells and mouse (C57BL/6) primary T cells. Naramura, Nature Immunology, 2002 (doi:10.1038/ni855): CBLB sets a threshold for TCR mediated signaling. - In murine primary CD4 T cells. Qiao, Molecular and Cellular Biology, 2008 (doi:10.1128/MCB.01505-07): CBLB regulation of NFkB activation. - In murine T cells.

HGNC:1541 Reviews: Kane, Current Opinion in Immunology, 2000 (doi:10.1016/S0952-7915(00)00083-2): TCR signaling review. Duan, Immunity, 2004 (doi:10.1016/j.immuni.2004.06.012): CBL role in downregulation of signaling receptors. Thien, Biochemical Journal, 2005 (doi:10.1042/BJ20050892): CBL is activated by Fyn, it is recruited to the Signalosome after TCR engegment. It downregulates Z chain and Zap70 activity. Kannan, The International Journal of Biochemistry and Cell Biology, 2012 (doi:10.1016/j.biocel.2012.08.023): TCR signaling review. Bartelt, Wiley interdisciplinary reviews. Systems biology and medicine, 2013 (doi:10.1002/wsbm.1194): LAT integrate signals from TCR. Pappers: Thien, The EMBO Journal, 2005 (doi:10.1038/sj.emboj.7600841): CCBL is anegative regulator of TCR signaling. - In murine Thymocytes. Poltorak, Cell Communication And Signaling, 2013 (doi:10.1186/1478-811X-11-4): TCR signaling dynamics. - In human primary T cells and Jurkat T-cell line J.CaM1.6.

HGNC:1541 Reviews: Kane, Current Opinion in Immunology, 2000 (doi:10.1016/S0952-7915(00)00083-2): TCR signaling review. Thien, Biochemical Journal, 2005 (10.1042/BJ20050892): CBL is activated by Fyn, it is recruited to the Signalosome after TCR engegment. It downregulates Z chain and Zap70 activity. Bartelt, Wiley interdisciplinary reviews. Systems biology and medicine, 2013 (10.1002/wsbm.1194): LAT integrate signals from TCR. Papers: Naramura, Nature Immunology, 2002 (10.1038/ni855): CCBL induces ligand-induced TCR downmodulation.. - In murine primary CD4 T cells. Thien, The EMBO Journal, 2005 (10.1038/sj.emboj.7600841): CCBL is anegative regulator of TCR signaling. - In murine Thymocytes.

HGNC:1736 Reviews: Tybulewicz, Current Opinion in Immunology, 2005 (doi:10.1016/j.coi.2005.04.003): Review on VAV proteins. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Bartelt, Wiley interdisciplinary reviews. Systems biology and medicine, 2013 (doi:10.1002/wsbm.1194): LAT integrate signals from TCR. Matalon, Immunological Reviews, 2013 (doi:10.1111/imr.12112): Actin remodeling Papers: Kim, Nature, 2000 (doi:10.1038/35004513): Regulations of WASp activation. - Purified recombinant proteins. Cannon, Immunity, 2001 (10.1016/S1074-7613(01)00178-9): WASp activation. - In E6 Jurkat T cells, JCaM-1 transfectants expressing wild-type Lck, and T cell blasts specific for OVA peptide. Tartare-Deckert, Journal of Biological Chemistry, 2001 (doi:10.1074/jbc.M010588200): Vav2 and Vav1 activate c-Fos Serum Response Element. - In Simian virus 40 T antigen-transfected human leukemic Jurkat T cells (Jurkat-TAg) and Jurkat clone JE6.1. Charvet, The Journal of Biological Chemistry, 2002 (doi:10.1074/jbc.M111627200): VAV1 and VAV2 mediate SRF activation and c-FOS expresion through RAC1/CDC42 pathways. - In Jurkat T cells (clone JE6.1), and simian virus 40 T antigen-transfected human leukemic Jurkat T cells (Jurkat-TAg). Labno, Current Biology, 2003 (doi:10.1016/j.cub.2003.08.005): Itk role in Actin remodeling. - In primary T cell blasts from wild-type (wt), Itk-/-, Rlk-/-,or Rlk-/- Itk-/- TCR transgenic mice. Foucault, BLOOD,2005 (doi:10.1182/blood-2003-08-2965):3BP2 intracts with Vav and regulates NFAT activation: - In the human B (BJAB, RPMI8866, Daudi, and Raji) and T (Jurkat) cell lines. Chemin, Journal of Immunology, 2012 (doi:10.4049/jimmunol.1200156): CDC42 regulates actin remodeling. - In Human primary CD4+ T cells and Jurkat J77 cl20 T cells.

HGNC:9588 Reviews: Harris, The Journal of Biological Chemistry (doi:10.1074/jbc.R700044200):Phosphoinositide Lipid Phosphatases. Buckler, Immunological Reviews, 2008 (doi:10.1111/j.1600-065X.2008.00650.x): Review on PTEN Hemmings, Cold Spring Harbor Perspectives in Biology, 2012 (doi:10.1101/cshperspect.a011189): PI3K pathway. Newton, Frontiers in Immunology, 2012 (doi:10.3389/fimmu.2012.00151): PTEN in T cells. Papers: Buckler, Journal of Immunology, 2006, (doi:10.4049/jimmunol.177.7.4262): PTEN imposes a requirement of CD28 costimulation for the induction of the PI3K pathway. - In murine (OT-II) primary CD4 T cells.

HGNC:6079 Reviews: Gloire, Biochemical Society Transactions, 2007 (doi: 10.1042/BST035027710.1042/BST0350277): Review on SHIP-1. Harris, The Journal of Biological Chemistry (doi:10.1074/jbc.R700044200):Phosphoinositide Lipid Phosphatases. Parry, Biochimica et Biophysica Acta, 2010 (10.1016/j.bbapap.2009.09.019): Review on SHIP-1. Balla, Physiological Reviews, 2013 (doi:10.1152/physrev.00028.2012): Phosphoinositides regulation. Srivastava, Frontiers in Immunology, 2013 (doi:10.3389/fimmu.2013.00288): Phosphoinositides regulation.

Reviews: Pao, Annual Reviews Immunology, 2007 (doi: 10.1146/annurev.immunol.23.021704.115647): ERK phosphorylate Lck in S59, preventing PTPN6 recruitment and Lck inactivation. Huse, Journal Of Cell Science, 2009 (doi:10.1242/jcs.042762): Shp1 dephosphorylate Lck. Hebeisen, Journal of Clinical Investigation, 2013: ERK phosphorylates Lck and prevents its association with PTPN6 (SHP1). Papers: Stefanova, Nature Immunology, 2003 (doi:10.1038/ni895): ERK phosphorylates LCK and prevents PTPN6 (SHP1)-mediated LCK inhibition. - In mouse T cells, 5C.C7 T cells, and 293T cells.

HGNC:9644 Reviews: Saito, Immunological Reviews, 2003 (PMID:12670402): Negatve feedback of T cell activation. Pao, Annual Reviews Immunology, 2007 (doi:10.1146/annurev.immunol.23.021704.115647): Reviews on Phosphatases. Papers: Yamasaki, Journal of Biological Chemistry, 2001 (doi:10.1074/jbc.M105384200): GAB2 recruitment and activation. - In T cell lines: 21-1-8, Jurkat and 2B4. Yamasaki, Mollecular And Cellular Biology, 2003 (doi:10.1128/MCB.23.7.2515): GAB2 interacts with GRAP2 and GRB2 for inhibiting TCR signals. - Jurkat T, Jurkat J.EcoR cells, LAT-deficient Jurkat cell line J.CaM2.5, and SLP- 76-deficient Jurkat cell line J.14. Arnaud, The Biochemical Journal, 2004 (doi:10.1042/BJ20040103): GAB2-SHP2 interaction. Zhang, Molecular Cell, 2004 (doi:10.1016/S1097-2765(04)00050-4): SHP2 regulats CSK. - In 3T2 and 293 cell lines.

HGNC:9652 Reviews: Pao, Annual Reviews Immunology, 2007 (doi:10.1146/annurev.immunol.23.021704.115647i): Reviews on Phosphatases. Chakraborty and Weiss, Nature Immunology, 2014 (doi:10.1038/ni.2940): PTPN22 dephosphorylates LCK pTyr394. Papers: Wu, The Journal Of Biological Chemistry, 2006 (doi:10.1074/jbc.M600498200): PTPN22(LYP) dephosphorylates and inhibits Lck, ZAP70,Vav, CD3e y TCRZ. - In Jurkat and 293T cells Vang, Nature Chemical Biology, 2012 (doi:10.1038/nchembio.916.): LYP inhibits TCR signaling. - In Human primary CD4 T cells and Jurkat cells.

HGNC:11896 Reviews: Harhaj, Immunological Reviews, 2012 (DOI:10.1111/j.1600-065X.2012.01100.x): A20 is expressed at a basal value in T cells, It is further induced/activated by IKK-NF-kB activation. Ma, Nature Reviews. Immunology, 2012 (DOI:10.1038/nri3313): A20 inhibits TCR-induced NF-kB activation. Papers: Duwel, The Journal of Immunology, 2009 (DOI: 10.4049/jimmunol.0803313): A20 deubiquitinates Malt1 complex and inhibits IKK and NF-kB activity. - In Jurkat T cells and Human T cells.

HGNC:3071 HGNC:17909 Reviews: Patterson, Biochemical Journal, 2009 (doi:10.1042/BJ20082234): Review on DUSPS. Papers: Kumabe, Microbiology and Immunology, 2010 (doi:10.1111/j.1348-0421.2009.00188.x): DUSP16 negatively regulates JNK. - In murine naive CD4 and CD8 T cells.

HGNC:30043 Reviews: Torgersen, The Journal of Biological Chemistry, 2001 (10.1074/jbc.C100014200): PAG regulates CSK during TCR signaling. Davidson, Mollecular And Cellular Biology, 2003 (10.1128/MCB.23.6.2017): PAG interacts with Csk to inhibit Lck activation. TCR ligation induces the disociation of PAG-Csk interaction and promotes T cell activation. Solheim, The Journal of Biological Chemistry, 2008 (10.1074/jbc.M705215200): PAG is phosphorylated by FYN which recruits CSK to the Immunological synapse. Salmond, Immunological Reviews, 2009 (10.1111/j.1600-065X.2008.00745.x): LCK and FYN function in TCR signaling to activate T Cells. Brownlie, Nature Reviews. Immunology, 2013 (10.1038/nri3403): Review on TCR signaling.

HGNC:9314 HGNC:9315 Reviews: Macián, Oncogene, 2001 (doi:10.1038/sj.onc.1204386): NFAT and AP-1 activation. Hogan, Genes and Development, 2003 (doi:10.1101/gad.1102703.GENES): Calcineurin/NFAT pathway. Macian, Nature Reviews. Immunology, (doi:10.1038/nri1632): Review on NFAT Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Liu, Immunological Reviews, 2009 (doi:10.1111/j.1600-065X.2008.00756.x): Cabin1 Gachet, General physiology and biophysics, 2009 (PMID: 20093726): Calcineuron/NFAT signaling.

HGNC:3040 Reviews: Macian, Nature Reviews. Immunology, (doi:10.1038/nri1632): Review on NFAT Liu, Immunological Reviews, 2009 (doi:10.1111/j.1600-065X.2008.00756.x): Cabin1

HGNC:1442 REviews: Macián, Oncogene, 2001 (doi:10.1038/sj.onc.1204386): NFAT and AP-1 activation. Hogan, Genes and Development, 2003 (doi:10.1101/gad.1102703.GENES): Calcineurin/NFAT pathway. Macian, Nature Reviews. Immunology, (doi:10.1038/nri1632): Review on NFAT Racioppi, TRENDS in Immunology, 2008 (doi:10.1016/j.it.2008.08.005): CAMKIV Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Gachet, General physiology and biophysics, 2009 (PMID: 20093726): Calcineuron/NFAT signaling. Papers: Yu, The Journal of Immunology, 2001 (doi:10.4049/jimmunol.166.1.284): CREB activation by TCR/CD28 signals. Inferred. - In EL4 T lymphoma cells.

HGNC:1460 HGNC:1461 Reviews: Domańska-Janik, Acta neurobiologiae experimentalis, 1996 (PMID: 8768309): Review in Protein Serine/threonine kinases. Mayr, Nature Reviews. Molecular Cell Biology, 2001 (doi:10.1038/35085068): Review on CREB. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation.

HGNC:1464 Reviews: Mayr, Nature Reviews. Molecular Cell Biology, 2001 (doi:10.1038/35085068): Review on CREB. Racioppi, TRENDS in Immunology, 2008 (doi:10.1016/j.it.2008.08.005): CAMKIV Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Liu, Immunological Reviews, 2009 (doi:10.1111/j.1600-065X.2008.00756.x): Cabin1 Papers: Yu, The Journal of Immunology, 2001 (doi:10.4049/jimmunol.166.1.284): CREB activation by TCR/CD28 signals. - In EL4 T lymphoma cells.

Reviews: Schulze-Luehrmann, Immunity, 2006 (doi:10.1016/j.immuni.2006.10.010): TCR signaling to NFkB. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Blonska, Cell Research, 2011 (doi:10.1038/cr.2010.182): NFkB activation by CARMA.

HGNC:16393 Reviews: Schulze-Luehrmann, Immunity, 2006 (doi:10.1016/j.immuni.2006.10.010): TCR signaling to NFkB. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Blonska, Cell Research, 2011 (doi:10.1038/cr.2010.182): NFkB activation by CARMA.

HGNC:375 Reviews: Macian, Nature Reviews. Immunology, (doi:10.1038/nri1632): Review on NFAT

HGNC:936 Reviews: Vanhaesebroeck, the Biochemical Journal, 2000 (doi:10.1042/0264-6021:3460561): PI3K, PDK, and Akt activation. Bauer, Molecular Immunology, 2002 (doi:10.1016/S0161-5890(02)00011-1): PKC and Akt are partners in TCR/CD28 signaling. Isakov, Annual Reviews. Immunology, 2002 (doi:10.1146/annurev.immunol.20.120701.074321): Akt inhibits BAD and apoptosis. Takada, Nature Reviews. Immunology, 2009 (doi:10.1038/nri2657): T cell homeostasis. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Hemmings, Cold Spring Harbor Perspectives in Biology, 2012 (doi:10.1101/cshperspect.a011189): PI3K pathway. Newton, Frontiers in Immunology, 2012 (doi:10.3389/fimmu.2012.00151): PTEN in T cells.

HGNC:989 Reviews: Schulze-Luehrmann, Immunity, 2006 (doi:10.1016/j.immuni.2006.10.010): TCR signaling to NFkB. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Blonska, Cell Research, 2011 (doi:10.1038/cr.2010.182): NFkB activation by CARMA. Papers:

Reviews: Macián, Oncogene, 2001 (doi:10.1038/sj.onc.1204386): NFAT and AP-1 activation. Hogan, Genes and Development, 2003 (doi:10.1101/gad.1102703.GENES): Calcineurin/NFAT pathway. Racioppi, TRENDS in Immunology, 2008 (doi:10.1016/j.it.2008.08.005): CAMKIV Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Brownlie, Nature Reviews. Immunology, 2013 (doi:10.1038/nri3403): Review on TCR signaling. Papers: Yu, The Journal of Immunology, 2001 (doi:10.4049/jimmunol.166.1.284): CREB activation by TCR/CD28 signals. - In EL4 T lymphoma cells.

HGNC:24187 Reviews: Liu, Immunological Reviews, 2009 (doi:10.1111/j.1600-065X.2008.00756.x): Cabin1

Reviews: Tybulewicz, Current Opinion in Immunology, 2005 (doi:10.1016/j.coi.2005.04.003): Review on VAV proteins. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Gu, Immunological Reviews, 2009 (doi:10.1111/j.1600-065X.2008.00751.x): Review on Abl. Brownlie, Nature Reviews. Immunology, 2013 (doi:10.1038/nri3403): Review on TCR signaling. Matalon, Immunological Reviews, 2013 (doi:10.1111/imr.12112): Actin remodeling Papers: Kaga, Journal of Immunology, 1998: Rac1 in the rearrangement of Cytoskeleton. - In mouse T cell line EL4. Salojin, Journal of Immunology, 1999 (PMID: 10395678): TCR and CD28 are coupled through Zap70 to the activation of Vav-Rac1-p38 pathway. - In Lck-negative JCaM1.6 cells, the human Jurkat cell line E6.1, P116 ZAP-70-deficient cell line (a variant of the Jurkat E6.1 T cell line), the EL4 mouse T cell line and CHO cells. Charvet, The Journal of Biological Chemistry, 2002 (doi:10.1074/jbc.M111627200): VAV1 and VAV2 mediate SRF activation and c-FOS expresion through RAC1/CDC42 pathways. - In Jurkat T cells (clone JE6.1), and simian virus 40 T antigen-transfected human leukemic Jurkat T cells (Jurkat-TAg). Foucault, BLOOD,2005 (doi:10.1182/blood-2003-08-2965):3BP2 intracts with Vav and regulates NFAT activation: - In the human B (BJAB, RPMI8866, Daudi, and Raji) and T (Jurkat) cell lines. Qu, Biochemistry, 2005 (doi:10.1021/bi048353o): Function of 3BP2 phosphorylation. - In Jurkat T lymphocytes expressing SV40 large T antigen (Jurkat-TAg cells). Haubert, Cellular Signaling, 2010 (doi:10.1016/j.cellsig.2010.02.001): Vav1 signaling in TCR/CD28 stimulated T cells. - In Jurkat T cell line (ATCC, clone E6.1) and 293T cells.

Reviews: Brownlie, Nature Reviews. Immunology, 2013 (doi:10.1038/nri3403): Review on TCR signaling. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Papers: Tartare-Deckert, Journal of Biological Chemistry, 2001 (doi:10.1074/jbc.M010588200): Vav2 and Vav1 activate c-Fos Serum Response Element. - In Simian virus 40 T antigen-transfected human leukemic Jurkat T cells (Jurkat-TAg) and Jurkat clone JE6.1. Charvet, The Journal of Biological Chemistry, 2002 (doi:10.1074/jbc.M111627200): VAV1 and VAV2 mediate SRF activation and c-FOS expresion through RAC1/CDC42 pathways. - In Jurkat T cells (clone JE6.1), and simian virus 40 T antigen-transfected human leukemic Jurkat T cells (Jurkat-TAg). Foucault, BLOOD,2005 (doi:10.1182/blood-2003-08-2965):3BP2 intracts with Vav and regulates NFAT activation: - In the human B (BJAB, RPMI8866, Daudi, and Raji) and T (Jurkat) cell lines. Qu, Biochemistry, 2005 (doi:10.1021/bi048353o): Function of 3BP2 phosphorylation. - In Jurkat T lymphocytes expressing SV40 large T antigen (Jurkat-TAg cells).

HGNC:9801 Reviews: Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Brownlie, Nature Reviews. Immunology, 2013 (doi:10.1038/nri3403): Review on TCR signaling. Papers: Kaga, Journal of Immunology, 1998 (PMID:9551951): Rac1 in the rearrangement of Cytoskeleton. - In mouse T cell line EL4. Salojin, Journal of Immunology, 1999 (PMID: 10395678): TCR and CD28 are coupled through Zap70 to the activation of Vav-Rac1-p38 pathway. - In Lck-negative JCaM1.6 cells, the human Jurkat cell line E6.1, P116 ZAP-70-deficient cell line (a variant of the Jurkat E6.1 T cell line), the EL4 mouse T cell line and CHO cells. Charvet, The Journal of Biological Chemistry, 2002 (doi:10.1074/jbc.M111627200): VAV1 and VAV2 mediate SRF activation and c-FOS expresion through RAC1/CDC42 pathways. - In Jurkat T cells (clone JE6.1), and simian virus 40 T antigen-transfected human leukemic Jurkat T cells (Jurkat-TAg). Foucault, BLOOD, 2005 (doi:10.1182/blood-2003-08-2965):3BP2 intracts with Vav and regulates NFAT activation: - In the human B (BJAB, RPMI8866, Daudi, and Raji) and T (Jurkat) cell lines. Qu, Biochemistry, 2005 (doi:10.1021/bi048353o): Function of 3BP2 phosphorylation. - In Jurkat T lymphocytes expressing SV40 large T antigen (Jurkat-TAg cells).

HGNC:9829 Reviews: Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Kannan, The International Journal of Biochemistry and Cell Biology, 2012 (doi:10.1016/j.biocel.2012.08.023): TCR signaling review. Papers: Reynolds, The Journal of Biological chemistry, 2004 (doi:10.1074/jbc.M400257200): Vav1 functions in TCR signaling. - In mouse thymocites

HGNC:5173 Reviews: Saibil, Current Opinion in Immunology, 2007 (doi:10.1016/j.coi.2007.08.005): Anergy and Cell Cycle. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Stone, Genes and Cancer, 2011 (doi:10.1177/1947601911408082): RASGRP1 activation. Kannan, The International Journal of Biochemistry and Cell Biology, 2012 (doi:10.1016/j.biocel.2012.08.023): TCR signaling review. Bartelt, Wiley interdisciplinary reviews. Systems biology and medicine, 2013 (doi:10.1002/wsbm.1194): LAT integrate signals from TCR. Jun, Frontiers in Immunology, 2013 (doi:10.3389/fimmu.2013.002399): Regulation of Ras activation. Papers: Ebinu, BLOOD, 2000 (PMID: 10807788): RASGRP1 activation. - In Jurkat T cells. Salojin, Journal of Immunology, 1999 (PMID: 10395678): TCR and CD28 are coupled through Zap70 to the activation of Vav-Rac1-p38 pathway. - In Lck-negative JCaM1.6 cells, the human Jurkat cell line E6.1, P116 ZAP-70-deficient cell line (a variant of the Jurkat E6.1 T cell line), the EL4 mouse T cell line and CHO cells. Reynolds, The Journal of Biological chemistry, 2004 (doi:10.1074/jbc.M400257200): Vav1 functions in TCR signaling. - In mouse thymocites Kortum, Science Signaling, 2013 (doi:10.1126/scisignal.2004494): SOS1 ability to oligomerize with LAT. - In DP thymocites.

HGNC:9878 Reviews: Ebinu. Science, 1998 (doi:10.1126/science.280.5366.1082): RASGRP1 activation. Stone, Genes and Cancer, 2011 (doi:10.1177/1947601911408082): RASGRP1 activation. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Kannan, The International Journal of Biochemistry and Cell Biology, 2012 (10.1016/j.biocel.2012.08.023): TCR signaling review. Bartelt, Wiley interdisciplinary reviews. Systems biology and medicine, 2013 (doi:10.1002/wsbm.1194): LAT integrate signals from TCR. Jun, Frontiers in Immunology, 2013 (doi:10.3389/fimmu.2013.002399): Regulation of Ras activation. Krishna, Frontiers in Immunology, 2013 (doi:10.3389/fimmu.2013.00178): DGKs Papers: Ebinu, BLOOD, 2000 (PMID: 10807788): RASGRP1 activation. - In Jurkat T cells. Reynolds, The Journal of Biological chemistry, 2004 (doi:10.1074/jbc.M400257200): Vav1 functions in TCR signaling. - In mouse thymocites

HGNC:12434 Reviews: Schaefer, Current Opinion In Immunology, 2000 (doi:10.1016/S0952-7915(00)00088-1): Lck phosphorylates Itk and Rlk, and they phosphorylate and activates PLCg. Itk requires PIP3. ZAP70 indirectly mediates Itk phosphorylation. Rlk phosphorylates SLP76. Kane, Current Opinion in Immunology (doi:10.1016/S0952-7915(00)00083-2): TCR signaling review. August, The Journal of Biochemistry And Celullar Biology, 2002 (doi:10.1016/S1357-2725(02)00068-7): Lck phosphorylates and activates ZAP70, Itk and Rlk. Zap70 phosphorylates LAT and SLP76. Itk and Rlk phosphorylate PLCg. Berg, Annual Review of Immunology, 2005 (doi:10.1146/annurev.immunol.22.012703.104743): Review on Tec kinases. Felices, Advances In Immunology, 2007 (doi:10.1016/S0065-2776(06)93004-1): Itk and Rlk phosphorylate PLCg with the requirement of LAT-SLP76. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Readinger, Immunological Reviews, 2009 (doi:10.1111/j.1600-065X.2008.00757.x): Review on Tec kinases. Papers: Schaefer, Science, 1999 (doi:10.1126/science.284.5414.638):Itk and Rlk roles in TCR signaling. - In murine T cells.

HGNC:10430 Reviews: Mayr, Nature Reviews. Molecular Cell Biology, 2001 (doi:10.1038/35085068): Review on CREB. Papers: Yu, The Journal of Immunology, 2001 (doi:10.4049/jimmunol.166.1.284): CREB activation by TCR/CD28 signals. - In EL4 T lymphoma cells. Appleman, Journal of Immunology, 2002, (doi:10.4049/jimmunol.168.6.2729): CD28 and TCR signals mediate PI3K activation and Cell Cycle progression. Inferred. - In human peripheral T cells.

HGNC:10825 Papers: Deckert, Immunity, 1998 (doi:10.1016/S1074-7613(00)80657-3): 3BP2 functions. - In Jurkat-TAg cells, Wild-type Jurkat (clone E6.1), CEM, HUT-78, Raji, U937, Jurkat cells lacking Zap-70 (P116), murine CD4+ DBHy3 and CD8+ B3Z T cell hybridomas. Charvet, The Journal of Biological Chemistry, 2002 (doi:10.1074/jbc.M111627200): Vav activates SFR through MEK kinase. - In Jurkat T cells (clone JE6.1) and simian virus 40 T antigen-transfected human leukemic Jurkat T cells (Jurkat-TAg). Foucault, BLOOD,2005 (doi:10.1182/blood-2003-08-2965):3BP2 intracts with Vav and regulates NFAT activation: - In the human B (BJAB, RPMI8866, Daudi, and Raji) and T (Jurkat) cell lines. Qu, Biochemistry, 2005 (doi:10.1021/bi048353o): Function of 3BP2 phosphorylation. - In Jurkat T lymphocytes expressing SV40 large T antigen (Jurkat-TAg cells).

HGNC:12733 Reviews: Gu, Immunological Reviews, 2009 (doi:10.1111/j.1600-065X.2008.00751.x): Review on Abl. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Matalon, Immunological Reviews, 2013 (doi:10.1111/imr.12112): Actin remodeling Papers: Charvet, The Journal of Biological Chemistry, 2002 (doi:10.1074/jbc.M111627200): VAV1 and VAV2 mediate SRF activation and c-FOS expresion through RAC1/CDC42 pathways. - In Jurkat T cells (clone JE6.1), and simian virus 40 T antigen-transfected human leukemic Jurkat T cells (Jurkat-TAg). Huang, BLOOD, 2008 (doi:10.1182/blood-2007-10-118232): Abl role in actin remodeling. - In Jurkat T cells and mouse primary CD4 T cells.

HGNC:8975 Reviews: Vanhaesebroeck, the Biochemical Journal, 2000 (doi:10.1042/0264-6021:3460561): PI3K, PDK, and Akt activation. Bauer, Molecular Immunology, 2002 (doi:10.1016/S0161-5890(02)00011-1): PKC and Akt are partners in TCR/CD28 signaling. Okkenhaug, Biochemical Society Transactions, 2004: PI3K role in T cell activation. Huang, Journal Of Biological Chemistry, 2004 (doi:10.1074/jbc.R400012200): Review on TCR signaling. Schulze-Luehrmann, Immunity, 2006 (doi:10.1016/j.immuni.2006.10.010): TCR signaling to NFkB. Saibil, Current Opinion in Immunology, 2007 (doi:10.1016/j.coi.2007.08.005): Anergy and Cell Cycle. Buckler, Immunological Reviews, 2008 (doi:10.1111/j.1600-065X.2008.00650.x): Regulation of T cell responses by PTEN. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Takada, Nature Reviews. Immunology, 2009 (doi:10.1038/nri2657): T cell homeostasis. Riha, Self/nonself, 2010 (doi:10.4161/self.1.3.12968): CD28 co-signaling. Parry, Biochimica et Biophysica Acta, 2010 (doi:10.1016/j.bbapap.2009.09.019): Review on SHIP-1. Hemmings, Cold Spring Harbor Perspectives in Biology, 2012 (doi:10.1101/cshperspect.a011189): PI3K pathway. Newton, Frontiers in Immunology, 2012 (doi:10.3389/fimmu.2012.00151): PTEN in T cells. Gamper, Frontiers in Immunology, 2012 (doi:10.3389/fimmu.2012.00312): PI3K, mTOR-dependent and -independent pathways. Chen, Nature Reviews. Immunology, 2013 (doi:10.1038/nri3405): Co-signaling receptors. Okkenhaug, Annual Reviews. Immunology, 2013 (doi:10.1146/annurev-immunol-032712-095946): Signaling by PI3K. Hermida, Advances in Biological Regulation, 2017 (doi:10.1016/j.jbior.2017.06.003): GSK3b functions. Papers: Bauer, The Journal of Biological Chemistry, 2001 (doi:10.1074/jbc.M103098200): Akt and PKCtheta activation of NFkB. - In transfected Jurkat T cells. Harriague, Nature Immunology, 2002(doi:10.1038/ni847): PIP3 generation at the Immunological synapse. - In T8 cell lina and Human CD4 T cells. Appleman, Journal of Immunology, 2002, (doi:10.4049/jimmunol.168.6.2729): CD28 and TCR signals mediate PI3K activation and Cell Cycle progression. - In human primary T cells. Thebault, Molecular Immunology, 2003 (doi:10.1016/j.molimm.2003.10.014): TCR/CD28 activation of PKCtheta. - In primary murine T cells, DPK cell line, DCEK-ICAM cell line, Jurkat (E6.1) cell line and 298T cell line. Garcon, Blood, 2008 (doi:10.1182/blood-2007-08-108050): CD28 costimulation. - In murin (OT-II T-cell) primary CD4 T cells. Sauer, PNAS, 2008 (doi:10.1073/pnas.0800928105): TCR/CD28 activate PI3K/Akt/mTOR pathway to induce FoxP3 expression. - In murine transgenic CD4 T cells. Shim, Journal of Immunology, 2011 (doi:10.4049/jimmunol.1001785): LAT and SLP76 are necesary for PI3K activation. - In Jurkat T cells (wt, J14 and JCam2).

HGNC:7794 Reviews: Gantke, Immunological Reviews, 2012 (DOI:10.1111/j.1600-065X.2012.01104.x): IKK inhibits p105 which inhibits Tpl-2. Vallabhapurapu, Annual Review of Immunology, 2009 (DOI:10.1146/annurev.immunol.021908.132641): P105 functions as an IkB.

HGNC:12731 Reviews: Tybulewicz, Current Opinion in Immunology, 2005 (doi:10.1016/j.coi.2005.04.003): Review on VAV proteins. Gu, Immunological Reviews, 2009 (doi:10.1111/j.1600-065X.2008.00751.x): Review on Abl. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Bartelt, Wiley interdisciplinary reviews. Systems biology and medicine, 2013 (doi:10.1002/wsbm.1194): LAT integrate signals from TCR. Matalon, Immunological Reviews, 2013 (doi:10.1111/imr.12112): Actin remodeling Papers. Kim, Nature, 2000 (doi:10.1038/35004513): Regulations of WASp activation. - Purified recombinant proteins. Cannon, Immunity, 2001 (10.1016/S1074-7613(01)00178-9): WASp activation. - In E6 Jurkat T cells, JCaM-1 transfectants expressing wild-type Lck, and T cell blasts specific for OVA peptide. Labno, Current Biology, 2003 (doi:10.1016/j.cub.2003.08.005): Itk role in Actin remodeling. - In primary T cell blasts from wild-type (wt), Itk-/-, Rlk-/-,or Rlk-/- Itk-/- TCR transgenic mice. Chemin, Journal of Immunology, 2012 (doi:10.4049/jimmunol.1200156): CDC42 regulates actin remodeling. - In Human primary CD4+ T cells and Jurkat J77 cl20 T cells.

HGNC:4844 Reviews: Gu, Immunological Reviews, 2009 (doi:10.1111/j.1600-065X.2008.00751.x): Review on Abl. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Papers: Gomez, Immunity, 2006, (doi:10.1016/j.immuni.2006.03.022): HS1 regulates actin remodeling. - In Jurkat T cells, pri-mary human CD4+ T cells, and murine DO11.10 TCR Tg T cells. Huang, BLOOD, 2008 (doi:10.1182/blood-2007-10-118232): Abl role in actin remodeling. - In Jurkat T cells and mouse primary CD4 T cells.

HGNC:169 HGNC:170 Reviews: Tybulewicz, Current Opinion in Immunology, 2005 (doi:10.1016/j.coi.2005.04.003): Review on VAV proteins. Smith-Garvin, Annual Review of Immunology, 2009 (doi:10.1146/annurev.immunol.021908.132706): TCR signaling and activation. Gu, Immunological Reviews, 2009 (doi:10.1111/j.1600-065X.2008.00751.x): Review on Abl. Matalon, Immunological Reviews, 2013 (doi:10.1111/imr.12112): Actin remodeling Papers: Kim, Nature, 2000 (doi:10.1038/35004513): Regulations of WASp activation. - Purified recombinant proteins. Labno, Current Biology, 2003 (doi:10.1016/j.cub.2003.08.005): Itk role in Actin remodeling. - In primary T cell blasts from wild-type (wt), Itk-/-, Rlk-/-,or Rlk-/- Itk-/- TCR transgenic mice. Gomez, Immunity, 2006, (doi:10.1016/j.immuni.2006.03.022): HS1 regulates actin remodeling. Inferred. - In Jurkat T cells, pri-mary human CD4+ T cells, and murine DO11.10 TCR Tg T cells. Chemin, Journal of Immunology, 2012 (doi:10.4049/jimmunol.1200156): CDC42 regulates actin remodeling. - In Human primary CD4+ T cells and Jurkat J77 cl20 T cells.

HGNC=3942 Reviews: Kannan, The International Journal of Biochemistry and Cell Biology, 2012 (doi: 10.1016/j.biocel.2012.08.023): TCR signaling review. Waickman, Immunological Reviews, 2012 (doi:10.1111/j.1600-065X.2012.01152.x): mTOR/Akt pathway. Hemmings, Cold Spring Harbor Perspectives in Biology, 2012 (doi:10.1101/cshperspect.a011189): PI3K pathway. Gamper, Frontiers in Immunology, 2012 (doi:10.3389/fimmu.2012.00312): PI3K, mTOR-dependent and -independent pathways. Chen, Nature Reviews. Immunology, 2013 (doi:10.1038/nri3405): Co-signaling receptors. Okkenhaug, Annual Reviews. Immunology, 2013 (doi:10.1146/annurev-immunol-032712-095946): Signaling by PI3K. Hermida, Advances in Biological Regulation, 2017 (doi:10.1016/j.jbior.2017.06.003): GSK3b functions.

HGNC:6860 Reviews: Vanhaesebroeck, the Biochemical Journal, 2000 (doi:10.1042/0264-6021:3460561): PI3K, PDK, and Akt activation. Schulze-Luehrmann, Immunity, 2006 (doi:10.1016/j.immuni.2006.10.010): TCR signaling to NFkB. Symons, TRENDs in Immunology, 2006 (DOI:10.1016/j.it.2005.11.007): MAPKs in Immunity. Papers: Kane, Molecular and Cellular Biology, 2002 (DOI:10.1128/MCB.22.16.5962): Akt phosphorylates cot (MAP3K8) and activates NF-kB pathway. - In Jurkat T cells and 293 T cells.

Several proteins Reviews: Holmberg, Trends in Biochemical Sciences, 2002 (doi:10.1016/S0968-0004(02)02207-7): NFAT inactivation by pshosphorylation.